Remyelination Therapy for Multiple Sclerosis By Jordan Burnett With Dr. Gullo https://uchicagomed.files.wordpress.com/2015/03/multiple_s clerosis.jpg.

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Presentation transcript:

Remyelination Therapy for Multiple Sclerosis By Jordan Burnett With Dr. Gullo clerosis.jpg

Multiple Sclerosis Past Treatments Intro to Remyelination Remyelinating drug trials Why I chose this project – Father has Primary-progressive MS – Interested in the developing treatments Overview and Inspiration

An immune- mediated/autoimmune disease Immune system attacks myelin Four types: 1. Relapsing-remitting 2. Secondary-progressive 3. Primary-progressive 4. Progressive-relapsing Multiple Sclerosis content/uploads/2014/02/Multiple-Sclerosis-myelin.jpg

Slow disease progression – Immune modulating drugs o More beneficial in Relapsing-remitting Treat relapses Manage symptoms Rehabilitate functioning Past Treatments

app=desktop Remyelination

Generation of new myelin sheaths around axons in adult brains Two major steps 1. Oligodendrocyte Progenitor Cells (OPCs) colonize lesions 2. OPCs differentiate into myelinating oligodendrocytes Remyelination

Remyelinating drugs: – Anti-LINGO-1 – rHIgM22 – Anti-SEMA4D Many more in trial Remyelination /c0b c6a-11d4-8c de0829/bio1.jpg

Is remyelination a feasible treatment for MS? What are the drugs in trial for remyelination? – How were these drug targets discovered? – What are the drugs’ mechanisms? Research Questions

sema4d-antibody-targeting-ms.html Chari, Divya M. “Remyelination in Multiple Sclerosis”. International Review of Neurobiology. 79 (2007): Web. 14 Feb announces-phase-1-results-for-remyelinating-antibody-in-multiple- sclerosis/ Works Cited