Objectives Describe: Antibiotic resistance High priority resistant organisms in long term care settings Key strategies for combating antibiotic resistance

Part I Antibiotic Resistance

Why care about antibiotic resistance? Antibiotic resistant infections are harder to treat and cause more complications ―Higher morbidity and mortality ―Few treatment options ―Last resort drugs have more side effects ―Some infections untreatable ―More expensive to treat ―Transmission to other patients ―Broad spectrum antibiotic use leads to more resistant infections

Antibiotic resistance is a global public health emergency Hundreds of thousands of deaths each year due to antibiotic resistance 25,000 38,000 23,000 58,000 babies

High burden of antibiotic resistant infections in the US 2 million infections, ¼ are foodborne $20 billion excess healthcare costs $35 billion lost productivity In WA, estimated 40,000 infections 460 deaths Source: CDC, 2013

Why? AR Prevalence

Antibiotic use key driver of resistance CDC CDDEP ECDC

Australian One Health Antimicrobial Resistance Colloquium, 2013 Bacterial resistance closely follows antibiotic development

CDC Antibiotic Resistance Threats in the US, 2013 * * * * * * * *

Found in soil, water and other moist environments Serious infections in those with underlying conditions, may cause minor infections in healthy people (hot tub folliculitis, swimmers ear, eye infections) Reservoirs in healthcare settings: disinfectants, respiratory equipment, food, sinks, taps, mops Pseudomonas