Identification of human nephron progenitors capable of generation of kidney structures and functional repair of chronic renal disease by Orit Harari ‐

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Identification of human nephron progenitors capable of generation of kidney structures and functional repair of chronic renal disease by Orit Harari ‐ Steinberg, Sally Metsuyanim, Dorit Omer, Yehudit Gnatek, Rotem Gershon, Sara Pri ‐ Chen, Derya D. Ozdemir, Yaniv Lerenthal, Tzahi Noiman, Herzel Ben ‐ Hur, Zvi Vaknin, David F. Schneider, Bruce J. Aronow, Ronald S. Goldstein, Peter Hohenstein, and Benjamin Dekel EMBO Mol Med. Volume 5(10): October 2, 2013 ©2013 by European Molecular Biology Organization

NCAM1 expression in mouse embryonic kidney organ and hFK serum ‐ free cultures Mouse embryonic kidney organ culture stained for Ncam1, Six2 and E ‐ cad as indicated. Orit Harari ‐ Steinberg et al. EMBO Mol Med. 2013;5: ©2013 by European Molecular Biology Organization

Characterization of immunosorted NCAM1+ subpopulation A.RT ‐ PCR analysis of gene expression in NCAM1 cell fractions. Orit Harari ‐ Steinberg et al. EMBO Mol Med. 2013;5: ©2013 by European Molecular Biology Organization

Segment ‐ specific differentiation of NCAM1+ cells on chick CAM A.Summarizing table of chick CAM results (cell type, cells/egg, visible grafts and grafts with tubule ‐ like formations).B,C.H&E staining of paraffin ‐ embedded sections of 5 × 105 NCAM1− (B) and 5... Orit Harari ‐ Steinberg et al. EMBO Mol Med. 2013;5: ©2013 by European Molecular Biology Organization

hNPC treatment in the 5/6 Nx chronic renal injury model A,B.hNPCs engraft into 5/6 Nx mouse kidneys: (A) hNPCs were labelled with CM ‐ Dil Cell Tracker and injected directly into the renal parenchyma. Orit Harari ‐ Steinberg et al. EMBO Mol Med. 2013;5: ©2013 by European Molecular Biology Organization