S PIKE LATENCY AND JITTER OF NEURONAL MEMBRANE PATCHES WITH STOCHASTIC H ODGKIN –H UXLEY CHANNELS Mahmut Ozer, MuhammetUzuntarla, Matjaž Perc, Lyle J.Graham.

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Presentation transcript:

S PIKE LATENCY AND JITTER OF NEURONAL MEMBRANE PATCHES WITH STOCHASTIC H ODGKIN –H UXLEY CHANNELS Mahmut Ozer, MuhammetUzuntarla, Matjaž Perc, Lyle J.Graham * Zonguldak Karaelmas University, Turkey * University of Maribor, Slovenia * Laboratory of Neurophysics and Physiology, France * Journal of Theoretical Biology, VC Lab, Dept. of Computer Science, NTHU, Taiwan

O VERVIEW Introduction Stochastic Resonance Neuron Na, K Model and Methods Simulation data Real data Conclusion Reference 2 VC Lab, Dept. of Computer Science, NTHU, Taiwan

I NTRODUCTION Stochastic Resonance 3 VC Lab, Dept. of Computer Science, NTHU, Taiwan

I NTRODUCTION Neuron 4 VC Lab, Dept. of Computer Science, NTHU, Taiwan

I NTRODUCTION Neuron 5 VC Lab, Dept. of Computer Science, NTHU, Taiwan

I NTRODUCTION Na, K 6 VC Lab, Dept. of Computer Science, NTHU, Taiwan

M ODEL AND M ETHODS Hodgkin and Huxley model (H-H) Noise 7 VC Lab, Dept. of Computer Science, NTHU, Taiwan

M ODEL AND M ETHODS Mean Latency(ML) Standard Deviation of the Latencies 8 VC Lab, Dept. of Computer Science, NTHU, Taiwan

R ESULTS Dependence of latency and jitter on channel noise during spontaneous firing 9 VC Lab, Dept. of Computer Science, NTHU, Taiwan

R ESULTS Dependence of latency and jitter on channel noise and input frequency 10 VC Lab, Dept. of Computer Science, NTHU, Taiwan

R ESULTS Dependence of latency and jitter on the initial input phase 11 VC Lab, Dept. of Computer Science, NTHU, Taiwan

C ONCLUSION NDD(noise delayed decay) Low-pass filter in subthreshold regions Channels may enhance the range of input frequencies for effective detection of first spikes 12 VC Lab, Dept. of Computer Science, NTHU, Taiwan

R EFERENCE Daqing Guo, Chunguang Li, Stochastic and coherence resonance in feed-forward-loop neuronal network motifs, Physical Review E 79, aspx?dataId=f594b906-2b27-11d4-b17f- 0050bae32d5f 13 VC Lab, Dept. of Computer Science, NTHU, Taiwan