The AIDS resistance of naturally SIV-infected sooty mangabeys is independent of cellular immunity to the virus by Richard Dunham, Paola Pagliardini, Shari.

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Presentation transcript:

The AIDS resistance of naturally SIV-infected sooty mangabeys is independent of cellular immunity to the virus by Richard Dunham, Paola Pagliardini, Shari Gordon, Beth Sumpter, Jessica Engram, Abeer Moanna, Mirko Paiardini, Judith N. Mandl, Benton Lawson, Seema Garg, Harold M. McClure, Yong-Xian Xu, Chris Ibegbu, Kirk Easley, Nathalia Katz, Ivona Pandrea, Cristian Apetrei, Donald L. Sodora, Silvija I. Staprans, Mark B. Feinberg, and Guido Silvestri Blood Volume 108(1): July 1, 2006 ©2006 by American Society of Hematology

Viral load and CD4+ T-cell count in naturally SIV-infected SMs. (A) Viral load (SIV RNA copies/mL plasma) in 110 SIV-infected SMs included in this study. Richard Dunham et al. Blood 2006;108: ©2006 by American Society of Hematology

SIV-specific T-cell responses in naturally SIV-infected SMs. The responses were measured by intracellular cytokine staining for IFN-γ, TNF-α, and IL-2 in response to peptide pools encompassing the entire sequence of gag, pol, env, and nef genes of SIVmac239. Richard Dunham et al. Blood 2006;108: ©2006 by American Society of Hematology

CD8+ T-cell degranulation in response to SIV peptides in naturally SIV-infected SMs. In all experiments, degranulation was measured as the percentage of CD3+CD8+ T cells coexpressing CD69 and CD107a. Richard Dunham et al. Blood 2006;108: ©2006 by American Society of Hematology

Lack of correlation between magnitude or breadth of SIV-specific T-cell responses and viral load in naturally SIV-infected SMs. (A-B) The percent of SIV-specific CD3+CD8+ T cells (A) or CD3+CD8- T cells (B) was plotted along with SIV viremia (copies/mL plas... Richard Dunham et al. Blood 2006;108: ©2006 by American Society of Hematology

Lack of correlation between magnitude or breadth of SIV-specific T-cell responses and CD4+ T- cell counts in naturally SIV-infected SMs. (A-B) The percent of SIV-specific CD3+CD8+ T cells (A) or CD3+CD8- T cells (B) was plotted along with CD4+ T-cell counts... Richard Dunham et al. Blood 2006;108: ©2006 by American Society of Hematology

Similar magnitude or breadth of SIV-specific T-cell responses in naturally SIV-infected SMs grouped by infecting SIVsmm viral subtypes. Richard Dunham et al. Blood 2006;108: ©2006 by American Society of Hematology

Lack of correlation between magnitude of SIV-specific T-cell responses and the level of T-cell proliferation measured as fraction of Ki67+ T cells. Richard Dunham et al. Blood 2006;108: ©2006 by American Society of Hematology