The C. elegans Germline Stem Cell Niche Hall et al. 1999.

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The C. elegans Germline Stem Cell Niche Hall et al. 1999

oocyte sperm mitotic region meiotic region vulva embryo oocyte sperm mitotic region meiotic region vulva embryo spermatheca distal tip cell sheath pair #1 vulva uterus sheath pair #2 sheath pair #3 sheath pair #4 sheath pair #5

The Notch Signaling Pathway Delta/Serate/LAG-2 Family Ligands (DSL) Notch Receptors Presenilin cleaves the Notch intracellular domain upon ligand binding. The intracellular domain translocates to the nucleus where it interacts with TFs (CSL Family).

The Germline Proliferation Defective (Glp) Phenotype WT Germ Line glp-1 Mutant (nonfunctional) Stem cells are lost to differentiation as sperm. Austin and Kimble,1987

The Tumorous (Tum) Phenotype Stem cells accumulate at the expense of differentiation. glp-1 Mutant (hyperactive) Berry et al WT Germ Line