Do Now On lined paper: What are the possible offspring of a father who is Type AB and mother who is type O? Hint: Use a punnett square! Can any offspring.

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Presentation transcript:

Do Now On lined paper: What are the possible offspring of a father who is Type AB and mother who is type O? Hint: Use a punnett square! Can any offspring receive blood from the father? Support your answer with your understanding of A and B antigens and anti-A and anti-B antibodies

Answer NONE of the offspring could receive blood from the father – If type A, will have anti-B antibodies that will attack – If type B, will have anti-A antibodies that will attack

RH Factor

RH comes from experiments done on the Rhesus Monkey RH Factor is another way for scientists to categorize blood (blood types) Possible phenotypes: – RH factor Have it = RH positive (+) Don’t have it = RH negative (-)

Antigen/Antibody RH antigen – RH + Means you have RH Antigen – RH - Means you do not have RH Antigen RH Antibodies – RH + No antibodies (because they would recognize the RH factor on your blood cells and destroy them) – RH - Make antibodies against RH antigen (cannot receive + blood if you are -)

How is RH Factor Inherited? RH factor is inherited by a simple dominant and recessive relationship where: R = RH positive (dominant) r = RH negative (recessive) Example: – What are the possible blood types (+ or -) of a father who is heterozygous for RH + and a mother who is RH - ?

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Hemolytic Disease

Problem: Mother is Rh- and therefore creates anti-Rh antibodies after having her first Rh+ child If mom has another Rh+ child, her anti-Rh antibodies will attack the baby during pregnancy! Solution: Mother takes a shot of Rh immunoglobulin also known as RhoGAM – Prevents mom’s anti-Rh antibodies from “attacking” the Rh positive blood of the baby Taken around the 28 th week of pregnancy, then again after birth if the child is Rh (+)