IDH2 R172 mutations define a unique subgroup of patients with angioimmunoblastic T-cell lymphoma by Chao Wang, Timothy W. McKeithan, Qiang Gong, Weiwei.

Slides:

Advertisements

Similar presentations

Clinical, biologic, and pathologic features in 157 patients with angioimmunoblastic T-cell lymphoma treated within the Groupe d'Etude des Lymphomes de.

Advertisements

Diffuse large B-cell lymphoma: reduced CD20 expression is associated with an inferior survival by Nathalie A. Johnson, Merrill Boyle, Ali Bashashati, Stephen.

Lymphoma dissemination: the other face of lymphocyte homing by Steven T. Pals, David J. J. de Gorter, and Marcel Spaargaren Blood Volume 110(9):

DNA Methylation in Histone H3.3 Lysine to Methionine Mutants Ellie Degen with Stefan Lundgren, Siddhant Jain and Dr. Peter W. Lewis UW Department of Biomolecular.

A new biologic prognostic model based on immunohistochemistry predicts survival in patients with diffuse large B-cell lymphoma by Anamarija M. Perry, Teresa.

The proliferation gene expression signature is a quantitative integrator of oncogenic events that predicts survival in mantle cell lymphoma Andreas Rosenwald,

by Paul A. Carpenter, Meei-Li Huang, and George B. McDonald

Fabian Mohr, Konstanze Döhner, Christian Buske, Vijay P.S. Rawat

Enhanced DNA damage in IDH1 mutant glioma cells.

VH mutation status and VDJ rearrangement structure in mantle cell lymphoma: correlation with genomic aberrations, clinical characteristics, and outcome.

Homocysteine inhibits endothelial cell growth via DNA hypomethylation of the cyclin Agene by Md S. Jamaluddin, Irene Chen, Fan Yang, Xiaohua Jiang, Michael.

Do HSCs divide asymmetrically?

Gene expression profiling of peripheral T-cell lymphoma including γδ T-cell lymphoma by Kana Miyazaki, Motoko Yamaguchi, Hiroshi Imai, Tohru Kobayashi,

The revised International Prognostic Index (R-IPI) is a better predictor of outcome than the standard IPI for patients with diffuse large B-cell lymphoma.

Evidence for the involvement of a hematopoietic progenitor cell in systemic mastocytosis from single-cell analysis of mutations in the c-kit gene by A.

Implications of somatic mutations in the AML1 gene in radiation-associated and therapy-related myelodysplastic syndrome/acute myeloid leukemia by Hironori.

A Clinical Evaluation of the International Lymphoma Study Group Classification of Non-Hodgkin's Lymphoma Blood Volume 89(11): June 1, 1997 ©1997.

Fludarabine treatment of patients with chronic lymphocytic leukemia induces a p53-dependent gene expression response by Andreas Rosenwald, Eric Y. Chuang,

Superior Survival after Autologous vs

Deficient CEBPA DNA binding function in normal karyotype AML patients is associated with favorable prognosis by José Fos, Thomas Pabst, Vibor Petkovic,

Mutant DNMT3A: a marker of poor prognosis in acute myeloid leukemia

Two splice-factor mutant leukemia subgroups uncovered at the boundaries of MDS and AML using combined gene expression and DNA-methylation profiling by.

Mutant WT1 is associated with DNA hypermethylation of PRC2 targets in AML and responds to EZH2 inhibition by Subarna Sinha, Daniel Thomas, Linda Yu, Andrew.

What is a true ALCL? by Wolfram Klapper Blood Volume 124(9):

Treating limited-stage nodular lymphocyte predominant Hodgkin lymphoma similarly to classical Hodgkin lymphoma with ABVD may improve outcome by Kerry J.

Relationship of p53, bcl-2, and Tumor Proliferation to Clinical Drug Resistance in Non-Hodgkin's Lymphomas by Wyndham H. Wilson, Julie Teruya-Feldstein,

MiRNA deregulation by epigenetic silencing disrupts suppression of the oncogene PLAG1 in chronic lymphocytic leukemia by Christian Philipp Pallasch, Michaela.

PRDM1/BLIMP1 is commonly inactivated in anaplastic large T-cell lymphoma by Michela Boi, Andrea Rinaldi, Ivo Kwee, Paola Bonetti, Maria Todaro, Fabrizio.

by Wu-Guo Deng, Ying Zhu, and Kenneth K. Wu

Assessment of Capture and Amplicon-Based Approaches for the Development of a Targeted Next-Generation Sequencing Pipeline to Personalize Lymphoma Management

A distinctive subtype of t(14;18)-negative nodal follicular non-Hodgkin lymphoma characterized by a predominantly diffuse growth pattern and deletions.

Promoter hypermethylation of cancer-related genes: a strong independent prognostic factor in acute lymphoblastic leukemia by Jose Roman-Gomez, Antonio.

by Douglas D. Ross, Judith E. Karp, Tar T. Chen, and L. Austin Doyle

Inhibition of glycogen synthase kinase-3 activity leads to epigenetic silencing of nuclear factor κB target genes and induction of apoptosis in chronic.

Genome-wide epigenetic analysis delineates a biologically distinct immature acute leukemia with myeloid/T-lymphoid features by Maria E. Figueroa, Bas J.

by Paul A. Carpenter, Meei-Li Huang, and George B. McDonald

Global approach to the diagnosis of leukemia using gene expression profiling by Torsten Haferlach, Alexander Kohlmann, Susanne Schnittger, Martin Dugas,

Lymphoma spread? Target CD47-SIRPα!

IDH2R172 mutations define a unique subgroup of patients with angioimmunoblastic T-cell lymphoma by Chao Wang, Timothy W. McKeithan, Qiang Gong, Weiwei.

Expression of the Human Immunodeficiency Virus-Tat Gene in Lymphoid Tissues of Transgenic Mice Is Associated With B-Cell Lymphoma by Ramendra K. Kundu,

by Hiromi Gunshin, Carolyn N. Starr, Cristina DiRenzo, Mark D

by George Z. Rassidakis, Mauricio P. Oyarzo, and L. Jeffrey Medeiros

ATM gene inactivation in mantle cell lymphoma mainly occurs by truncating mutations and missense mutations involving the phosphatidylinositol-3 kinase.

Yang et al. SALL4 is a key regulator of survival and apoptosis in human leukemic cells. Blood. 2008;112(3):805–813. Blood Volume 114(14): October.

by Gregory H. Underhill, David George, Eric G. Bremer, and Geoffrey S

TBL1XR1/TP63: a novel recurrent gene fusion in B-cell non-Hodgkin lymphoma by David W. Scott, Karen L. Mungall, Susana Ben-Neriah, Sanja Rogic, Ryan D.

The Genetic Basis and Expanding Role of Molecular Analysis in the Diagnosis, Prognosis, and Therapeutic Design for Myelodysplastic Syndromes Grant E.

by Sansana Sawasdikosol, Kristin M. Russo, and Steven J. Burakoff

Determining cell-of-origin subtypes of diffuse large B-cell lymphoma using gene expression in formalin-fixed paraffin-embedded tissue by David W. Scott,

Loss of imprinting at the 14q32 domain is associated with microRNA overexpression in acute promyelocytic leukemia by Floriana Manodoro, Jacek Marzec, Tracy.

Volume 3, Issue 2, Pages (February 2003)

Clinicogenetic risk models predict early progression of follicular lymphoma after first-line immunochemotherapy by Vindi Jurinovic, Robert Kridel, Annette.

Volume 17, Issue 2, Pages (October 2016)

Genome-wide promoter methylation of hairy cell leukemia

Fabian Mohr, Konstanze Döhner, Christian Buske, Vijay P.S. Rawat

Significant differences in translational efficiencies of DNA damage repair pathway genes between patient clusters. Significant differences in translational.

Differential binding of H3K36me3 in G34-mutant KNS42 cells drives pediatric GBM expression signatures. Differential binding of H3K36me3 in G34-mutant KNS42.

Changes in mutation rate or protein abundance are not observed in HATs when comparing rho+ to rho0 cells. Changes in mutation rate or protein abundance.

Profiling of the TCRB-MYB cases by large-scale gene expression analysis. Profiling of the TCRB-MYB cases by large-scale gene expression analysis. (A) Heat.

Survival based on V gene mutation status and CD38 expression among B-CLL patients who stratify to the Rai intermediate risk category. Survival based on.

Distinct molecular and clinical correlates of H3F3A mutation subgroups

JAK2V617F leads to increased 5-hmC and genome-wide loss of cytosine methylation in primary patient samples. JAK2V617F leads to increased 5-hmC and genome-wide.

Relationship of PMBL to Hodgkin lymphoma.

Angioimmunoblastic T-cell lymphoma: the many-faced lymphoma

CREBBP loss-of-function results in gene expression repression signature. CREBBP loss-of-function results in gene expression repression signature. A–D,

Patient Tregs express normal levels of suppression.

Identification of putative TET1 targets in TNBC

Driver pathways and key genes in OSCC

Outcomes in patients with PTCL

Genome-wide DNA hypomethylation associated with DNMT3A mutation in murine and human FLT3ITD AML. Human: A–C, volcano plot (A) representation of mean methylation.

Presentation transcript:

IDH2 R172 mutations define a unique subgroup of patients with angioimmunoblastic T-cell lymphoma by Chao Wang, Timothy W. McKeithan, Qiang Gong, Weiwei Zhang, Alyssa Bouska, Andreas Rosenwald, Randy D. Gascoyne, Xiwei Wu, Jinhui Wang, Zahid Muhammad, Bei Jiang, Joseph Rohr, Andrew Cannon, Christian Steidl, Kai Fu, Yuping Li, Stacy Hung, Dennis D. Weisenburger, Timothy C. Greiner, Lynette Smith, German Ott, Eleanor G. Rogan, Louis M. Staudt, Julie Vose, Javeed Iqbal, and Wing C. Chan Blood Volume 126(15): October 8, 2015 ©2015 by American Society of Hematology

Mutational profiles of IDH2, TET2, DNMT3A, and RHOA in patients with PTCLs. (A) Co- occurrence of IDH2R172, TET2, DNMT3, and RHOA mutations in patients with AITL (n = 39), subgroups of PTCL-NOS (n = 41), and ALK(−) ALCL (n = 12). Chao Wang et al. Blood 2015;126: ©2015 by American Society of Hematology

IDH2R172 mutations define a unique subgroup of AITL with distinct gene expression. Chao Wang et al. Blood 2015;126: ©2015 by American Society of Hematology

Functional annotation of genes differentially expressed between IDH2/TET2 double-mutant AITL and TET2 single-mutant AITL. (A) Selected top IPA canonical pathways differing between IDH2/TET2 double-mutant AITL and TET2 single-mutant AITL. (B) IPA upstream an... Chao Wang et al. Blood 2015;126: ©2015 by American Society of Hematology

IDH2R172 mutations are associated with DNA hypermethylation in AITL and T cells. Chao Wang et al. Blood 2015;126: ©2015 by American Society of Hematology

Genes with aberrant expression associated with aberrant methylation in AITL. RRBS methylation analysis (left) and gene expression analysis (right) are shown for 46 hypermethylated and 9 hypomethylated genes between 18 AITL and 7 normal samples. Chao Wang et al. Blood 2015;126: ©2015 by American Society of Hematology

Poised genes tend to be downregulated and hypermethylated in IDH2R172 mutant AITL. (A) GSEA analysis of genes differentially expressed between TET2-single mutant and IDH2/TET2- double mutant groups shows the enrichment of H3K27me3-associated genes. Chao Wang et al. Blood 2015;126: ©2015 by American Society of Hematology

IDH2R172 mutant alters histone lysine trimethylation in Jurkat T cells and AITL. (A) Western blots showing ectopic expression of wild-type IDH2 and IDH2R172 in whole cell lysates of transduced Jurkat cells. Chao Wang et al. Blood 2015;126: ©2015 by American Society of Hematology