Inducible caspase-9 suicide gene controls adverse effects from alloreplete T cells after haploidentical stem cell transplantation by Xiaoou Zhou, Gianpietro.

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Inducible caspase-9 suicide gene controls adverse effects from alloreplete T cells after haploidentical stem cell transplantation by Xiaoou Zhou, Gianpietro Dotti, Robert A. Krance, Caridad A. Martinez, Swati Naik, Rammurti T. Kamble, April G. Durett, Olga Dakhova, Barbara Savoldo, Antonio Di Stasi, David M. Spencer, Yu-Feng Lin, Hao Liu, Bambi J. Grilley, Adrian P. Gee, Cliona M. Rooney, Helen E. Heslop, and Malcolm K. Brenner Blood Volume 125(26): June 25, 2015 ©2015 by American Society of Hematology

The kinetics of T-cell subsets after iC9-T-cell infusion in patients not treated with AP1903. Xiaoou Zhou et al. Blood 2015;125: ©2015 by American Society of Hematology

iC9-T-cell engraftment and in vivo allodepletion by dimerizer drug. Xiaoou Zhou et al. Blood 2015;125: ©2015 by American Society of Hematology

Antiviral immune reconstitution after iC9–T-cell infusion. Xiaoou Zhou et al. Blood 2015;125: ©2015 by American Society of Hematology

Virus-specific T cells are retained and remain functional after administration of AP1903. Xiaoou Zhou et al. Blood 2015;125: ©2015 by American Society of Hematology

Administration of AP1903 rapidly resolves GVHD symptoms and reduces cytokine release. Xiaoou Zhou et al. Blood 2015;125: ©2015 by American Society of Hematology

Administration of AP1903 affects iC9-T cells in CSF. Detection of iC9-T cells in CSF and PB by flow cytometry before and after administration of AP1903 (Pt. 6). Xiaoou Zhou et al. Blood 2015;125: ©2015 by American Society of Hematology