Date of download: 7/7/2016 From: The Pathophysiologic Roles of Interleukin-6 in Human Disease Ann Intern Med. 1998;128(2):127-137. doi:10.7326/0003-4819-128-2-199801150-00009.

Slides:



Advertisements
Similar presentations
Adrenal gland. Anatomy Components Two compartments –Adrenal Cortex (outer layer) Three layers –Zona glomerulosa (15 %) –Zona fasciculata (75 %) –Zona.
Advertisements

Copyright © 2006 by Elsevier, Inc. Endocrine Cells of the Hypothalamohypopyseal Axis & the Portal Circulation Median eminence Stalk Neurohypophysis Vein.
Date of download: 5/31/2016 From: Polymorphonuclear Leukocytes in Non-Insulin-dependent Diabetes Mellitus: Abnormalities in Metabolism and Function Ann.
Date of download: 5/31/2016 From: The Pathogenesis of Mucosal Inflammation in Murine Models of Inflammatory Bowel Disease and Crohn Disease Ann Intern.
Date of download: 6/1/2016 From: A Physiologic Approach to Diagnosis of the Cushing Syndrome Ann Intern Med. 2003;138(12): doi: /
Date of download: 6/1/2016 From: Syndromes of Glucocorticoid Resistance Ann Intern Med. 1993;119(11): doi: /
Date of download: 6/2/2016 Copyright © 2016 McGraw-Hill Education. All rights reserved. Hypothalamic, pituitary, and adrenal cortical relationships. Solid.
Date of download: 6/3/2016 From: Mortality Rates in Elderly Patients Who Take Different Angiotensin-Converting Enzyme Inhibitors after Acute Myocardial.
Date of download: 6/3/2016 From: Sex, Age, and Birth Cohort Effects in Colorectal Neoplasms: A Cohort Analysis Ann Intern Med. 2010;152(11): doi: /
Date of download: 6/3/2016 From: Surgery Versus Nonsurgical Treatment of Lumbar Spinal Stenosis: A Randomized Trial Ann Intern Med. 2015;162(7):
Date of download: 6/3/2016 From: Elevated Plasma Homocysteine Level Is an Independent Predictor of Coronary Heart Disease Events in Patients with Type.
Date of download: 6/3/2016 From: Increased Incidence of Aortic Aneurysm and Dissection in Giant Cell (Temporal) Arteritis: A Population- Based Study Ann.
Date of download: 6/3/2016 From: The Effect of Erythropoietin-Stimulating Agents on Health-Related Quality of Life in Anemia of Chronic Kidney Disease:
Date of download: 6/6/2016 From: Comparative Effectiveness of Pain Management Interventions for Hip Fracture: A Systematic Review Ann Intern Med. 2011;155(4):
Date of download: 6/17/2016 From: Interactions between the Hypothalamic-Pituitary-Adrenal Axis and the Female Reproductive System: Clinical Implications.
Date of download: 6/22/2016 From: The Efficacy of Influenza Vaccine in Elderly Persons: A Meta-Analysis and Review of the Literature Ann Intern Med. 1995;123(7):
Date of download: 6/23/2016 From: Glucocorticoid Therapy for Immune-Mediated Diseases: Basic and Clinical Correlates Ann Intern Med. 1993;119(12):
Date of download: 6/23/2016 From: Meta-Analysis: Acupuncture for Low Back Pain Ann Intern Med. 2005;142(8): doi: /
Date of download: 6/24/2016 From: Effectiveness of Manual Physical Therapy and Exercise in Osteoarthritis of the Knee: A Randomized, Controlled Trial Ann.
Date of download: 6/29/2016 From: Predicting Future Functional Status for Seriously Ill Hospitalized Adults: The SUPPORT Prognostic Model Ann Intern Med.
Date of download: 7/1/2016 From: Does Utilization of Screening Mammography Explain Racial and Ethnic Differences in Breast Cancer? Ann Intern Med. 2006;144(8):
Date of download: 7/5/2016 From: Risk Factors and Precipitants of Long-Term Disability in Community Mobility: A Cohort Study of Older Persons Ann Intern.
Date of download: 7/5/2016 From: Sunscreen and Prevention of Skin Aging: A Randomized Trial Ann Intern Med. 2013;158(11): doi: /
Date of download: 7/6/2016 From: Can Inexpensive Signs Encourage the Use of Stairs? Results from a Community Intervention Ann Intern Med. 1998;129(5):
Date of download: 7/8/2016 From: Did Medicare Part D Affect National Trends in Health Outcomes or Hospitalizations?: A Time-Series Analysis Ann Intern.
Date of download: 9/16/2016 From: Fluorouracil plus Levamisole as Effective Adjuvant Therapy after Resection of Stage III Colon Carcinoma: A Final Report.
Date of download: 9/17/2016 From: Behavioral Therapy to Enable Women with Urge Incontinence to Discontinue Drug Treatment: A Randomized Trial Ann Intern.
Date of download: 9/17/2016 From: Topical Treatment of Pressure Ulcers with Nerve Growth Factor: A Randomized Clinical Trial Ann Intern Med. 2003;139(8):
Date of download: 9/17/2016 From: Plasma Cytokine and Endotoxin Levels Correlate with Survival in Patients with the Sepsis Syndrome Ann Intern Med. 1993;119(8):
Date of download: 9/17/2016 From: Effects of Amiodarone on Thyroid Function Ann Intern Med. 1997;126(1): doi: /
Date of download: 9/17/2016 From: Dose Response to Vitamin D Supplementation in Postmenopausal Women: A Randomized Trial Ann Intern Med. 2012;156(6):
Date of download: 9/18/2016 From: The Cardiomyopathy of Overload: An Unnatural Growth Response in the Hypertrophied Heart Ann Intern Med. 1994;121(5):
Date of download: 9/18/2016 From: “Nonfunctional” Adrenal Tumors and the Risk for Incident Diabetes and Cardiovascular Outcomes: A Cohort Study Ann Intern.
Date of download: 9/18/2016 From: Somatostatin Receptor Scintigraphy: Its Sensitivity Compared with That of Other Imaging Methods in Detecting Primary.
Date of download: 9/19/2016 From: The Implications of Regional Variations in Medicare Spending. Part 2: Health Outcomes and Satisfaction with Care Ann.
Date of download: 9/19/2016 From: Pathogenesis, Natural History, Treatment, and Prevention of Hepatitis C Ann Intern Med. 2000;132(4): doi: /
Date of download: 9/20/2016 From: Breast Cancer in Black Women Ann Intern Med. 1996;124(10): doi: / Age-specific.
From: Screening for Syphilis Infection in Pregnancy: U. S
Ann Intern Med. 2010;153(7): doi: / Figure Legend:
Ann Intern Med. 2016;165(7): doi: /M Figure Legend:
From: High-Dose Melphalan and Autologous Stem-Cell Transplantation in Patients with AL Amyloidosis: An 8-Year Study Ann Intern Med. 2004;140(2):85-93.
Figure 1. A schematic representation of the stress system
From: Effects of Low-Carbohydrate and Low-Fat DietsA Randomized Trial
Ann Intern Med. 2016;164(8): doi: /M Figure Legend:
From: Systematic Review: Comparative Effectiveness of Treatments to Prevent Fractures in Men and Women with Low Bone Density or Osteoporosis Ann Intern.
Ann Intern Med. 2005;143(6): doi: / Figure Legend: Flow of evidence.
Ann Intern Med. 2014;160(11): doi: /M Figure Legend:
Ann Intern Med. 1999;130(6): doi: / Figure Legend:
From: Systematic Review: Strategies for Using Exercise Therapy To Improve Outcomes in Chronic Low Back Pain Ann Intern Med. 2005;142(9): doi: /
From: The Evolving Diabetes Burden in the United States
From: Long-Term Outcome of Anti–Glomerular Basement Membrane Antibody Disease Treated with Plasma Exchange and Immunosuppression Ann Intern Med. 2001;134(11):
Ann Intern Med. 2010;152(2): doi: / Figure Legend:
From: The In-Training Examination in Internal Medicine: An Analysis of Resident Performance over Time Ann Intern Med. 2002;137(6): doi: /
From: Nitric Oxide: A Physiologic Messenger
From: Treatment of Refractory Whipple Disease with Interferon-γ
From: Screening for Lung Cancer With Low-Dose Computed Tomography: A Systematic Review to Update the U.S. Preventive Services Task Force Recommendation.
From: Upper Endoscopy for Gastroesophageal Reflux Disease: Best Practice Advice From the Clinical Guidelines Committee of the American College of Physicians.
From: Doctoring to the Music of Time
From: Risk Factors for Prostate Cancer
From: Exercise Tomographic Thallium-201 Imaging in Patients with Severe Coronary Artery Disease and Normal Electrocardiograms Ann Intern Med. 1994;121(11):
From: Self-Measured Blood Pressure Monitoring in the Management of HypertensionA Systematic Review and Meta-analysis Ann Intern Med. 2013;159(3):
Biologic therapy of inflammatory bowel disease
Excitation BolsTORs Motor Neurons in ALS Mice
Biologic therapy of inflammatory bowel disease
Volume 140, Issue 3, Pages e5 (March 2011)
Duration of Glucocorticoid Treatment and Outcome in Sepsis
Adipose Tissue as an Endocrine Organ
ENDOCRINE SYSTEM.
Human Visceral-Fat-Specific Glucocorticoid Tuning of Adipogenesis
Adipose Tissue as an Endocrine Organ
Presentation transcript:

Date of download: 7/7/2016 From: The Pathophysiologic Roles of Interleukin-6 in Human Disease Ann Intern Med. 1998;128(2): doi: / Transcriptional regulation of the interleukin-6 (IL-6) promoter.Glucocorticoids inhibit transcription of interleukin-6 through interaction of the ligand-activated glucocorticoid receptor (GR) with the Re1A subunit of transcription factor NF-κB. Estrogens suppress transcription (slashed arrows) of interleukin-6 through formation of heteromeric estrogen receptor (ER)-C/EBPbeta and estrogen receptor-NF-κB complexes. AP-1 = AP-1 site; CREB = cyclic adenosine 5′-monophosphate-response element binding site; C/EBP = C/EBP binding site; NF-κB = NF-κB binding site. The triangle represents glucocorticoid; the rhombus represents estrogen. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

Date of download: 7/7/2016 From: The Pathophysiologic Roles of Interleukin-6 in Human Disease Ann Intern Med. 1998;128(2): doi: / Pleiotropy of interleukin-6 (IL-6) action.Binding of circulating interleukin-6 to the soluble interleukin-6 receptor (sIL-6R) may activate gp130 subunits present on cells that lack the specific interleukin-6 receptor, probably those that are activated by the leptin receptor (OB-R), leukemia inhibitory factor receptor (LIF-R) (for leukemia inhibitory factor, oncostatin-M, ciliary neurotrophic factor, and cardiotropin-1), and oncostatin-M receptor (OMR) (for oncostatin-M). Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

Date of download: 7/7/2016 From: The Pathophysiologic Roles of Interleukin-6 in Human Disease Ann Intern Med. 1998;128(2): doi: / Regulation of the secretion and endocrine actions of interleukin-6 (IL-6).Interleukin-6 production is stimulated by tumor necrosis factor-α (TNF-α) and interleukin-1 (IL-1). Interleukin-6, in turn, inhibits further production of tumor necrosis factor-α and interleukin-1. Catecholamines stimulate interleukin-6 production, whereas glucocorticoids, estrogens, and androgens suppress it. Interleukin-6 acutely stimulates the corticotropin-releasing hormone (CRH) neuron, which leads to increased secretion of adrenocorticotropin hormone (ACTH) and cortisol. It also stimulates the secretion of growth hormone (GH) and arginine vasopressin (AVP) (at high levels) but suppresses thyroid-stimulating hormone (TSH) secretion and levels of circulating lipids. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

Date of download: 7/7/2016 From: The Pathophysiologic Roles of Interleukin-6 in Human Disease Ann Intern Med. 1998;128(2): doi: / Changes in circulating hormones and interleukin-6 with aging in men and women. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

Feedback: Privacy Policy Feedback
Do Not Sell My Personal Information
About project: SlidePlayer Terms of Service

© 2025 SlidePlayer.com. Inc. All rights reserved.