MUSCLES LECTURE 14 CHAPTER 12 MECHANISMS OF CONTRACTION.

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MUSCLES LECTURE 14 CHAPTER 12 MECHANISMS OF CONTRACTION

MUSCLE STRUCTURE

Skeletal muscle cells (fibers) are multinuclear and have striations - under voluntary control; but also responds to reflexes.

STRUCTURE OF SKELETAL MUSCLE Figure 12.1

You should know everything on this slide from anatomy: --- Origin/Insertion --- flexor muscles/extensor muscles --- prime mover = agonist; in a flexion, the flexor is the agonist, and the extensor is the antagonist.

What’s Inside A Muscle Fiber (cell)?

Myofibrils contain myofilaments arranged into sarcomeres

Titin Filaments and M Lines M = Midline

Arrangement of Thick and Thin Filaments

HOW DOES A MUSCLE WORK?

Fig. 7.23

Fig. 7.26

Fig. 7.28

Review: Stimulating a Muscle Fiber

Stimulating a Muscle Fiber

ROLE OF CALCIUM

CLOSE UP OF POWER STROKE

REVIEW OF INTERACTION OF MYOSIN WITH ACTIN Click here to watch

Sliding Filament Theory of Muscle Contraction When a muscle contracts, sarcomeres (distance between the Z-lines shortens).

Muscle Relaxation a. Action potentials cease. b. Calcium release channels close c. Ca 2+ -ATPase pumps move Ca 2+ back into SR (active transport). d. No more Ca 2+ is available to bind to troponin e. Tropomyosin moves to block the myosin heads from binding to actin

Motor Units