Modulation of NF ‐ κB ‐ dependent transcription and cell survival by the SIRT1 deacetylase by Fan Yeung, Jamie E Hoberg, Catherine S Ramsey, Michael D.

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Presentation transcript:

Modulation of NF ‐ κB ‐ dependent transcription and cell survival by the SIRT1 deacetylase by Fan Yeung, Jamie E Hoberg, Catherine S Ramsey, Michael D Keller, David R Jones, Roy A Frye, and Marty W Mayo EMBO J. Volume 23(12): June 16, 2004 ©2004 by European Molecular Biology Organization

NAD ‐ dependent HDACs regulate NF ‐ κB transcription. Fan Yeung et al. EMBO J. 2004;23: ©2004 by European Molecular Biology Organization

SIRT1 interacts with the RelA/p65 subunit of NF ‐ κB. Fan Yeung et al. EMBO J. 2004;23: ©2004 by European Molecular Biology Organization

Resveratrol inhibits the transactivation potential of the RelA/p65 protein. Fan Yeung et al. EMBO J. 2004;23: ©2004 by European Molecular Biology Organization

SIRT1 deacetylates lysine 310 on RelA/p65. Fan Yeung et al. EMBO J. 2004;23: ©2004 by European Molecular Biology Organization

Resveratrol and SIRT1 inhibit the RelA/p65 transactivation domain by targeting lysine 310. Fan Yeung et al. EMBO J. 2004;23: ©2004 by European Molecular Biology Organization

Resveratrol potentiates chromatin ‐ bound SIRT1 to inhibit cIAP ‐ 2 gene expression. Fan Yeung et al. EMBO J. 2004;23: ©2004 by European Molecular Biology Organization

Enhanced Sirtuin activity sensitizes cells to TNFα ‐ induced apoptosis. Fan Yeung et al. EMBO J. 2004;23: ©2004 by European Molecular Biology Organization

Differential SIRT1 ‐ mediated repression of p53 and NF ‐ κB controls, life and death signals. Fan Yeung et al. EMBO J. 2004;23: ©2004 by European Molecular Biology Organization