Disruption of the trypanothione reductase gene of Leishmania decreases its ability to survive oxidative stress in macrophages by Carole Dumas, Marc Ouellette,

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Yellow dots mark the locus of a specific gene on a homologous pair of human chromosomes CHAPTER 14 THE HUMAN GENOME.

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Disruption of the trypanothione reductase gene of Leishmania decreases its ability to survive oxidative stress in macrophages by Carole Dumas, Marc Ouellette, Jorge Tovar, Mark L. Cunningham, Alan H. Fairlamb, Samira Tamar, Martin Olivier, and Barbara Papadopoulou EMBO J. Volume 16(10): May 15, 1997 ©1997 by European Molecular Biology Organization

Inactivation of L.donovani TR alleles. Carole Dumas et al. EMBO J. 1997;16: ©1997 by European Molecular Biology Organization

Translocation of part of the TR locus in L.donovani TR/TR::hyg/TR::neo mutant leading to partial trisomy for TR. (A) A restriction map of a genomic region of a 45 kb part of a 520 kb chromosome containing the TR locus. Carole Dumas et al. EMBO J. 1997;16: ©1997 by European Molecular Biology Organization

TR mRNA expression in the wild ‐ type and single and double TR targeted mutants of L.donovani. Carole Dumas et al. EMBO J. 1997;16: ©1997 by European Molecular Biology Organization

Infectivity of the L.donovani TR disruption mutants toward human monocytes differentiated into macrophages. Carole Dumas et al. EMBO J. 1997;16: ©1997 by European Molecular Biology Organization

Phenotype of L.major TR/TR::hyg mutant. Carole Dumas et al. EMBO J. 1997;16: ©1997 by European Molecular Biology Organization