Digital Pathology, An Introduction From glass slides to digital files and there after.

Slides:

Advertisements

Similar presentations

Quantitative Assessment of Tissue-based IHC Biomarkers

Advertisements

Image analysis In our test case we assessed ER in TMAs that have been created using tissue samples from a large epidemiological study (UK Anglian Breast.

International Telecommunication Union Workshop on Standardization in E-health Geneva, May 2003 Digital Imaging in Pathology for Standardization Yukako.

Maura Bidinost User Experience Designer Omnyx LLC Usability: A Critical Factor in the Successful Adoption of Digital Pathology for Routine Sign-out.

Introduction to Telepathology Bruce E. Dunn, M.D. Milwaukee VA Medical Center

Consideration on work items of IHE-pathology and DICOM for pathology image Sep Ikuo Tofukuji IHE-Japan Pathology-WG.

Rev B 09/2012 ChromoPlex 1 Dual Detection Multiply Your Capabilities Leica ChromoPlex TM 1 Dual Detection for Leica BOND.

Wednesday August 16, 2006 APIII 2006 Vancouver Breakout Session A2 Whole Slide Image System Implementation Jeffrey Fine MD University of Pittsburgh.

Digital Pathology for Improved Patient Care

An introductory guide to what is available today from Meyer Instruments, Inc. Imaging Insects with Digital Slide Scanners.

ACIS ® III Image Analysis Robert Carlson Manager, Imaging Systems *Accurate *Efficient *Consistent *Easy to use.

Digital Imaging Behind the Scenes Stacey Yates. Implemented Workflow Challenges/Solutions Added Value Future Plans Overview.

Javier J Rodríguez, MD, FCAP. “ Telemedicine, and consequentially telepathology is not a science of the future but of the present and is here to stay,

The digital pathology archive: the UMC Utrecht initiative

Measuring diagnostic accuracy of using digital slides in routine histopathology and analyzing sources of diagnostic errors László FÓNYAD 1st. Dept. of.

Telepathology Applications in VISN 12 Bruce E. Dunn, M.D. Milwaukee VA Medical Center

C4d - staining: Comparison of methods C. Seemayer, A. Gaspert, M. Mihatsch.

Magee-Womens Hospital of UPMC

Procedures used by CHTN

1 Historical overview of FDA regulation of digital pathology imaging applications: the safety and effectiveness issues Tremel A. Faison, MS, RAC, SCT(ASCP)

0 October 23, 2009 Formal Oral Presentation: FDA Hematology and Pathology Devices Panel of the Medical Devices Advisory Committee.

The New Care Team Model Connecting Pathologists into the Cancer Care Team with Enterprise Imaging.

Ronald S. Weinstein, M.D. Professor, Pathology Head, Pathology 1990 – 2007 Director, Arizona Telemedicine Program.

1 CLINICAL TRIALS Digital Pathology in the Era of Global Clinical Trials: Improving Quality and Consistency Ron Luff, MD, MPH.

Political and Strategic Aspects of Employing Digital Pathology in Pathology Departments John D. Pfeifer, MD, PhD Vice Chair for Clinical Affairs, Department.

TISSUE BIOREPOSITORY AND PATHOLOGY SERVICES. TISSUE PROCUREMENT Routinely collect tumor tissue, adjacent normal tissue, buffy coat, plasma, newly diagnosed.

High Volume Slide Scanning Architecture and Applications

High Performance Computing for Tissue MicroArray Analysis Dr Yinhai Wang David McCleary, Ching-Wei Wang, Jackie James, Dean Fennell, Peter Hamilton.

FDA Panel Digital Pathology Oct 22/23 Dirk Soenksen, President.

DICOM & pathology C. Daniel Le Bozec (GP Hospital) - USERS J

The Integration of Whole Slide Imaging in the Clinical Anatomic Pathology – Limitations of Laboratory Information Systems, Image Capture Systems and Archives.

FOR RESEARCH USE ONLY CONFIDENTIAL Page 1 Enabling Digital Pathology Enabling Digital Pathology September 2007.

MOTIC VM600 Virtual Microscope Development of Motic’s New Model; Features & Improvements, Model Strategy, and Model Competition Development of Motic’s.

Using Digital Pathology in a Multi-Site, Geographically Distributed Integrated Delivery Network Paul M Urie MD PhD The Digital Pathology Experience at.

Practical Issues on Clinical Validation of Digital Imaging Applications in Routine Surgical Pathology FDA Hematology and Pathology Devices Panel Meeting.

Image Quality in Digital Pathology (from a pathologist’s perspective) Jonhan Ho, MD, MS.

Real-Time Telepathology for Subspecialty Consultation Nikolaj Lagwinski, MD September 10 th, 2007.

Operational Considerations in Implementing Digital Pathology Pathology Visions 2009 Walter H. Henricks, M.D. Cleveland Clinic.

Pathology Reports Nicole Draper, MD.

The Results of Automated Image Analysis Workshop at the 10th European Congress on Telepathology and 4th International Congress on Virtual Microscopy Arvydas.

Wednesday August 16, 2006 APIII 2006 Vancouver Breakout Session A2 Integrating whole slide images into clinical workflow Jonhan Ho, MD Dermatopathology.

Greenstone in Practice: Implementations of an Open Source Digital Library System Allison Zhang Washington Research Library Consortium Upper Marlboro, Maryland.

Digital Imaging in Pathology Bruce E. Dunn, M.D. Milwaukee VA Medical Center

2011 NYU NMVB Report NYU Dept of Cardiothoracic Surgery NYU Dept of Pathology Monday November 7 th, 2011.

Digital Imaging in Education and Distributed Pathology Practice

Digital Imaging: Value Added, Finally Mike Isaacs Director of Information Technology John Pfeifer, MD, PhD Professor of Pathology Department of Pathology.

APERIO TELEPATHOLOGY IN MALAWI; AN INNOVATIVE SOLUTION TO LACK OF PATHOLOGISTS Dr Steve Kamiza, Consultant Histopathologist and Assoc. Professor, Malawi.

12 th European Congress on Digital Pathology previously European Congress on Telepathology and international Congress on Virtual Microscopy College des.

Date of download: 9/17/2016 Copyright © 2016 SPIE. All rights reserved. Spatial light interference microscopy (SLIM) optical setup. The phase is retrieved.

Digital Pathology, Past , Present and Future

Institute for Pathology, University Hospital Erlangen

Political and Strategic Aspects of Employing Digital Pathology in Pathology Departments John D. Pfeifer, MD, PhD Vice Chair for Clinical Affairs, Department.

Implementing a Digital Pathology System for Primary Diagnosis: The nuts & bolts Liron Pantanowitz MD Professor of Pathology & Biomedical Informatics Director.

Table 2. Association between histology grade, lymph node status,

The Royal Brompton & Harefield Hospitals’ Experience

FDA Panel Digital Pathology Oct 22/23

FDA Hematology and Pathology Devices Panel Meeting October 22-23, 2009

Tremel A. Faison, MS, RAC, SCT(ASCP) FDA/CDRH/OIVD/DIHD

Implementation and Validation of Telepathology

Prediction of breast cancer progression using nuclear morphometry

WSI-FS II: Validation of Squamous Cell Carcinoma Frozen Section Whole Slide Image Diagnosis in Surgical Pathology Vamsi Parimi MD1; Ryba Dominika, Ewa.

Tremel A. Faison, MS, RAC, SCT(ASCP) FDA/CDRH/OIVD/DIHD

Real-Time Telepathology in VISN 8

Development of A Digital Pathology Database for Annotation and Quality Management of a Brain Tumor Biorepository Jeremy Molligan, MD Pathology.

Digital Pathology Early Adoption Douglas J

Quantitative Measurement of Cell-Free Plasma DNA and Applications for Detecting Tumor Genetic Variation and Promoter Methylation in a Clinical Setting

A Novel Approach to Detect Programed Death Ligand 1 (PD-L1) Status and Multiple Tumor Mutations Using a Single Non–Small-Cell Lung Cancer (NSCLC) Bronchoscopy.

Six Key Principles Inclusiveness & Collaboration

Supplementary Fig S1, Zembutsu H et al.

Fig. 2. Deficiency of neuronal HS leads to reduced neuroinflammation.

Presentation transcript:

Digital Pathology, An Introduction From glass slides to digital files and there after

process Scanning of glass slides by a scanner--- convert information to a digital format Navigate the digital slide using a software, from any power, on any area of interest, just like a glass slide Data analysis

Applications Remote access of slides: Frozen Sections (night calls and remote sites) Telepathology for 2nd opinion Secondslide.com pathxchange.com Multi-institution collaborative studies Retrospective and prospective collections of cases for TMA, case series studies, etc

Real time consultation Bioimagene

Clinical applications Archival & viewing of data: – Tumor Boards – Quality Assurance (2 nd read on QA cases) – Publications (? digital slide access as a part of case reports and case series in the future?) – Scan in key diagnostic slides for outside review cases, to avoid having to borrow back slides for clinical or academic needs. – Access old cases for comparison for frozen sections and current cases – Teaching sets for rare cases.

Extract region

Image Management

Digital IHC From Aperio tutorial,

Bioimagene companion algorithm Breast: ER, PR, Her2neu, ki67, p53 quantitation Prostate: PIN-4 and Ki-67 Brain: Ki67 Heme: quantitation of CD138 labeled plasma cells in bone marrow samples. Carcinoid: BioImagene’s Ki-67 carcinoid algorithm is an aid to pathologists and researchers in the detection and quantitation of stained cells in carcinoid tumors derived from gastrointestinal tissues.

Practical issues Cost (machine, software, storage & personal) Time for scan: 15x15 mm tissue – 20x < 1min; 40 x 6-7 min Memory: 20X scan: 250 MB; 40X scan: 800 MB – 1TB can hold 2,070 slides (assuming 500 MB/slide), or 4000 slides for 20x (250 MB)

vendors Aperio Bioimagene Olympus (nanozoomer) Omnyx (UPMC+GE) 3DHistech Leica

Issues for evaluation Scanned image quality Image management software (interface with LIS system if intend for clinical use) Image analysis software Technical support Stability of vendor in the market Good fit between your need and vendor’s strong points