Activated Protein C Use In Sepsis - A Real Magic Bullet Dr. I. Krupe University Hospital Lewisham Department of Anaesthetics And Intensive Care Medicine.

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Presentation transcript:

Activated Protein C Use In Sepsis - A Real Magic Bullet Dr. I. Krupe University Hospital Lewisham Department of Anaesthetics And Intensive Care Medicine

Human Activated Protein C Endogenuous protein with -antithrombotic -profibrinolytic -antiinflammatory properties

Our Data APC started in January complete courses (96 hours)until March 2005

4 incomplete courses APC discontinued after 1 hour as indication was wrong 1 patient died before completion of course of pituitary gland necrosis APC discontinued due to impending surgery 1 septic patient died before completion of course of sepsis

2 courses of APC in 1 patient Patient with 2 ITU admissions due to chest infections, about 4 months apart

mortality

2003

2004

2005