Identification of Functional Elements and Regulatory Circuits by Drosophila modENCODE by, Sushmita Roy, Jason Ernst, Peter V. Kharchenko, Pouya Kheradpour,

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Presentation transcript:

Identification of Functional Elements and Regulatory Circuits by Drosophila modENCODE by, Sushmita Roy, Jason Ernst, Peter V. Kharchenko, Pouya Kheradpour, Nicolas Negre, Matthew L. Eaton, Jane M. Landolin, Christopher A. Bristow, Lijia Ma, Michael F. Lin, Stefan Washietl, Bradley I. Arshinoff, Ferhat Ay, Patrick E. Meyer, Nicolas Robine, Nicole L. Washington, Luisa Di Stefano, Eugene Berezikov, Christopher D. Brown, Rogerio Candeias, Joseph W. Carlson, Adrian Carr, Irwin Jungreis, Daniel Marbach, Rachel Sealfon, Michael Y. Tolstorukov, Sebastian Will, Artyom A. Alekseyenko, Carlo Artieri, Benjamin W. Booth, Angela N. Brooks, Qi Dai, Carrie A. Davis, Michael O. Duff, Xin Feng, Andrey A. Gorchakov, Tingting Gu, Jorja G. Henikoff, Philipp Kapranov, Renhua Li, Heather K. MacAlpine, John Malone, Aki Minoda, Jared Nordman, Katsutomo Okamura, Marc Perry, Sara K. Powell, Nicole C. Riddle, Akiko Sakai, Anastasia Samsonova, Jeremy E. Sandler, Yuri B. Schwartz, Noa Sher, Rebecca Spokony, David Sturgill, Marijke van Baren, Kenneth H. Wan, Li Yang, Charles Yu, Elise Feingold, Peter Good, Mark Guyer, Rebecca Lowdon, Kami Ahmad, Justen Andrews, Bonnie Berger, Steven E. Brenner, Michael R. Brent, Lucy Cherbas, Sarah C. R. Elgin, Thomas R. Gingeras, Robert Grossman, Roger A. Hoskins, Thomas C. Kaufman, William Kent, Mitzi I. Kuroda, Terry Orr-Weaver, Norbert Perrimon, Vincenzo Pirrotta, James W. Posakony, Bing Ren, Steven Russell, Peter Cherbas, Brenton R. Graveley, Suzanna Lewis, Gos Micklem, Brian Oliver, Peter J. Park, Susan E. Celniker, Steven Henikoff, Gary H. Karpen, Eric C. Lai, David M. MacAlpine, Lincoln D. Stein, Kevin P. White, and Manolis Kellis Science Volume 330(6012): December 24, 2010 Published by AAAS

Fig. 1 Overview of Drosophila modENCODE data sets. The modENCODE Consortium et al. Science 2010;330: Published by AAAS

Fig. 2 Coding and noncoding genes and structures. The modENCODE Consortium et al. Science 2010;330: Published by AAAS

Fig. 3 Chromatin-based annotation of functional elements. The modENCODE Consortium et al. Science 2010;330: Published by AAAS

Fig. 4 Discovery and characterization of chromatin states and their functional enrichments. The modENCODE Consortium et al. Science 2010;330: Published by AAAS

Fig. 5 High-occupancy TF binding regions and their relation to motifs, ORC, and chromatin. The modENCODE Consortium et al. Science 2010;330: Published by AAAS

Fig. 6 Genome coverage by modENCODE data sets. The modENCODE Consortium et al. Science 2010;330: Published by AAAS

Fig. 7 Properties of the physical regulatory network. The modENCODE Consortium et al. Science 2010;330: Published by AAAS

Fig. 8 Gene function prediction from coexpression and co-regulation patterns. The modENCODE Consortium et al. Science 2010;330: Published by AAAS

Fig. 9 Predictive models of regulator, region, and gene activity. The modENCODE Consortium et al. Science 2010;330: Published by AAAS