Kaplan-Meier Survival Plotting Macro %NEWSURV Jeffrey Meyers Mayo Clinic, Rochester, MN

2 Macro Overview (Plot)

3 Macro Overview (Statistical Report) General Statistical Report Table Example Event/Total Median (95% CI) † Hazard Ratio (95% CI) ‡ Survival Estimates (95% CI) † P-value SASHELP.BMT Data set with no Class Variable All Patients83/ ( )1 Years: 58.3 ( ) 2 Years: 42.0 ( ) This is the footnote for this model SASHELP.BMT Data set with Class Variable Group $ ALL24/381.1 (0.5-NE)Ref1 Years: 54.9 ( ) 2 Years: 35.3 ( ) AML-High Risk34/450.5 ( )1.47 ( )1 Years: 37.8 ( ) 2 Years: 24.4 ( ) AML-Low Risk25/546.0 (1.9-NE)0.56 ( )1 Years: 77.8 ( ) 2 Years: 61.1 ( ) This is the footnote for this model † Kaplan-Meier method; ‡ Cox model; $ Score test; This also allows an overall footnote

4 Sample Dataset  SASHELP.BMT  SAS 9.3  GROUP – categorical  Acute Lymphoblastic Leukemia (ALL)  Acute Myeloid Leukemia (AML) »High Risk and Low Risk  T – time from transplant  STATUS – survival status  0=Alive  1=Dead

5 Output Methods  RTF, PDF, HTML, Listing  Various file types (PNG, JPEG, TIFF, EMF, …)  DPI settings  Scalable vector graphics (9.3 and later)  From macro vs. within ODS tags

6 Error Checking  Macro checks most parameter input  Custom error messages: ERROR: (Model 1: DISPLAY): TOTL is not in the list of valid values ERROR: (Model 1: DISPLAY): Possible values are LEGEND|HR|MEDIAN|TOTAL|EVENT|TIMELIST| PVAL|TABLECOMMENTS ERROR: 1 pre-run errors listed ERROR: Macro NEWSURV will cease

7 Computed Statistics  1 LIFETEST procedures, up to 2 PHREG procedures  N patients, N events  Median time-to-event  Kaplan-Meier event-free rate  Cox proportional hazards ratio  Univariate and adjusted  P-value  Univariate and adjusted  Patients-at-risk numbers

8 Only Required Variables Required Parameters  DATA  TIME  CENS  CEN_VL

9 Dataset Transformations  XDIVISOR  CLASS  WHERE  LANDMARK

10 Line and Axes Transformations  COLOR  PATTERN  Axis options  Label  Minimum  Maximum  Increment

11 Plot Summary Table Options  DISPLAY  Class options  Alignment  Order  Reference  Time-points  Multiple  Unit label  P-value  Model  5 options  Stratification

12 New Features  Border and Wall options  Events/N formats  Split headers  Time-point without unit  Reference text  Factor level comparison P-values

13 Patients-at-Risk Table Variations  Labels  3 location options  Automatic  Values  Increment  Color  Location

14 Patients-at-Risk Table Variations  Header  Alignment  Turn on/off  User specified text

15 Patients-at-Risk Table Variations

16 Patients-at-Risk Table Variations

17 Lattice of Plots  Each cell individually customizable  Overall title  Cell titles  Overall footnote  Cell footnotes  1-S Plot

18 Closing  %NEWSURV greatly reduces effort required to build a Kaplan-Meier survival plot  Graph Template Language greatly reduces effort of building publication quality plots  Goals for the future:  Add capabilities for competing risks/cumulative incidence  Add ability to enter pre-built data set to be plotted

19 Contact Information Name: Jeffrey Meyers Enterprise: Mayo Clinic Address: 200 1st St SW City, State ZIP: Rochester, MN Work Phone: Twitter: jmeyers_spa SAS Community Wiki Page: LinkLink