 DRSG founded in 1994 as a specialty group of the SRA  Open to all interested in biological and mathematical relationships between exposure and effect.

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Presentation transcript:

 DRSG founded in 1994 as a specialty group of the SRA  Open to all interested in biological and mathematical relationships between exposure and effect  Focused on issues relating to the shapes and positions of dose-response curves and their underlying biological meaning; population distributions that describe interindividual variability in susceptibility and ranges of response; probabilistic approaches for projecting responses in unknown populations to assist in regulatory benefits analyses; and integrated use of mechanistic, animal, and epidemiologic data to aid in estimation of risks at low doses  Interests include chemical, physical, and microbial hazards that affect human populations and environmental species  Multidisciplinary expertise spans the fields of toxicology, medical microbiology, and environmental sciences Dose Response Specialty Group of the Society for Risk Analysis JOIN THE OPEN DRSG MONTHLY TELECONFERENCES  Open teleconferences first Tuesday of every month (noon -1 p.m. Eastern Time) to discuss and plan symposia, proposed workshops, open forums, and other DRSG- sponsored activities on dose response issues  New members and guests welcome  Three teleseminars with a presentation and discussion were held in 2010 March 3, 2009 Threshold of Toxicological Concern (TTC) Michael Laufersweiler, Procter & Gamble Central Product Safety Stephen Olin, ILSI Research Foundation August 3, 2010 Microbial Dose-Response & Its Use in Estimating the Benefits of EPA’s Drinking Water Rules Jeff Swartout, EPA National Center for Environmental Assessment Mike Messner, EPA Office of Ground Water and Drinking Water Stig Regli, EPA Office of Ground Water and Drinking Water September 7, 2010 The Use and Misuse of Dose Thresholds in Risk Assessment” Kenny Crump, Louisiana Tech University Call (513) on first Tuesdays of each month (except December) at noon – 1 pm EST; access code 2790# when prompted DOSE RESPONSE ASSESSMENT Definition: Process of characterizing quantitative relationships between the expected or observed incidence or degree of responses with exposure levels of chemical, physical, and biological hazards in animals, people, and the environment ISSUES OF INTEREST  Measuring and modeling variability in dose-response relationships  Normal and susceptible animals and humans  Host, agent, and environmental variability for dose-response  Low-dose extrapolations  Incorporating information on modes of action and repair/protection into dose- response assessments  Selection of surrogate agents in absence of quantitative data for agents of concern  Tissue dosimetry  Harmonization of cancer vs non-cancer endpoints for chemicals, chronic and acute adverse effects for microbial pathogens JOIN THE GROUP: Our website ( includes minutes of meetings and teleconference discussions, notices of current events, and miscellaneous information. See “Membership/How to Join” for more information on becoming a member. JOIN THE E_LIST ON YahooGroups.com: Go to and hit the “Join this Group!” button./ JOIN IN WORKSHOPS, SYMPOSIA, BUSINESS MEETING, AND MIXER: Annual DRSG business meeting is held on Monday noon during the national meeting. DRSG sponsors symposia and workshops at the national meetings, as well as a mixer, often in alliance with other SRA specialty groups DRSG STUDENT AWARD PROGRAM The DRSG student merit award program recognizes excellence in academic research related to dose-response assessment for chemical, physical, and microbial hazards. Society for Risk Analysis: a multidisciplinary, interdisciplinary, scholarly, international society that provides an open forum for all those who are interested in risk analysis. Contact SRA: phone: EXECUTIVE COMMITTEE Past Chair Paul Feder (Battelle, Columbus) Vice-Chair Paul Schlosser (NCEA/EPA) Secretary/Treasurer Julie Fitzpatrick (Consultant) Trustee-at-Large Kenny Crump (Louisiana Tech U) Trustee-at-Large Allen Davis (NCEA/EPA) Chair Jeff Gift (NCEA/EPA) Chair-Elect Lynne Haber (TERA) 2011 NEWLY ELECTED OFFICERS 2011 Secretary/Treasurer Peter McLure Syracuse Research Corp New York 2011 Trustee-at-Large Resha Putzrath Navy and Marine Corp Public Health Center 2011 Chair-Elect George Woodall (NCEA/EPA)