Tumor-derived circulating endothelial cell clusters in colorectal cancer by Igor Cima, Say Li Kong, Debarka Sengupta, Iain B. Tan, Wai Min Phyo, Daniel.

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Presentation transcript:

Tumor-derived circulating endothelial cell clusters in colorectal cancer by Igor Cima, Say Li Kong, Debarka Sengupta, Iain B. Tan, Wai Min Phyo, Daniel Lee, Min Hu, Ciprian Iliescu, Irina Alexander, Wei Lin Goh, Mehran Rahmani, Nur- Afidah Mohamed Suhaimi, Jess H. Vo, Joyce A. Tai, Joanna H. Tan, Clarinda Chua, Rachel Ten, Wan Jun Lim, Min Hoe Chew, Charlotte A. E. Hauser, Rob M. van Dam, Wei-Yen Lim, Shyam Prabhakar, Bing Lim, Poh Koon Koh, Paul Robson, Jackie Y. Ying, Axel M. Hillmer, and Min-Han Tan Sci Transl Med Volume 8(345):345ra89-345ra89 June 29, 2016 Published by AAAS

Fig. 1. Retrieval of circulating CD45− cell clusters using a microfiltration device. Igor Cima et al., Sci Transl Med 2016;8:345ra89 Published by AAAS

Fig. 2. Circulating CD45− cell clusters express EMT markers but do not harbor the mutations or chromosome abnormalities of matching primary tumors. Igor Cima et al., Sci Transl Med 2016;8:345ra89 Published by AAAS

Fig. 3. Circulating CD45− cell clusters from CRC patients are endothelial cells. Igor Cima et al., Sci Transl Med 2016;8:345ra89 Published by AAAS

Fig. 4. Circulating endothelial cell clusters are tumor-derived and are associated with features of the underlying tumor vasculature. Igor Cima et al., Sci Transl Med 2016;8:345ra89 Published by AAAS

Fig. 5. Tumor-derived endothelial cell clusters do not form by coagulation. Igor Cima et al., Sci Transl Med 2016;8:345ra89 Published by AAAS

Fig. 6. Tumor-derived endothelial cell clusters are prevalent in early-stage and treatment-naïve CRC patients and are affected by therapeutic intervention. Igor Cima et al., Sci Transl Med 2016;8:345ra89 Published by AAAS