Chapter 19. 섬유소용해계 억제인자 (1) alpha2-antiplasmin O inhibition: plasmin O 혈장에 plasminogen 의 절반 몰농도 존재 O synthesis in liver O 70%: plasminogen 과 결합, 30%: 유리형.

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Chapter 19. 섬유소용해계 억제인자 (1) alpha2-antiplasmin O inhibition: plasmin O 혈장에 plasminogen 의 절반 몰농도 존재 O synthesis in liver O 70%: plasminogen 과 결합, 30%: 유리형 O plasmin 의 lysine-binding site 와 결합 O plasmin 의 serine 과 covalent binding O fibrin 의 lysine 과 covalent binding by XIIIa

(2) alpha2-macroglobulin O homotetramer O synthesis in liver cell, fibroblast, macrophage O chronic pulmonary disease, metastasis 시 : decrease O inhibition: plasmin, thrombin, kallikrein (3) Plasmingen activator inhibitor-1 O inhibition: sct-PA, tct-PA, tcu-PA O synthesis in endothelial cell, adipocyte O vitronectin + uPAR or integrin -> uPA activation PAI-1 가 competitive inhibition: uPAR or intergin binding 억제

(4) Plasmingen activator inhibitor-2 O ovalbumin-related serpin family (ov-serpins) O synthesis in monocyte O inhibition: tcu-PA O pregnancy, M4, M5 급성골수성백혈병, 악성종양 환자에서 증가 (5) Plasmingen activator inhibitor-3 (protein C inhibitor) O inhibition: protein C, kallikrein, XIa, Xa, thrombin O heparin: activity 증가 O synthesis in liver (6) C1-esterase inhibitor O inhibition: XIIa, XIa, kallikrein, plasmin O synthesis in liver (7) Histidine-rich glycoprotein O inhibition: plasminogen (8) thrombin-activatable finrinolysis inhibitor (TAFI) O procarboxypeptidase B, procarboxypeptidase U O synthesis in liver O activation by thrombin (thrombomodulin), trypsin, kallikrein, plasmin O inhibition: plasmin