Formation of human hepatocytes by human hematopoietic stem cells in sheep by Graça Almeida-Porada, Christopher D. Porada, Jason Chamberlain, Ali Torabi,

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Presentation transcript:

Formation of human hepatocytes by human hematopoietic stem cells in sheep by Graça Almeida-Porada, Christopher D. Porada, Jason Chamberlain, Ali Torabi, and Esmail D. Zanjani Blood Volume 104(8): October 15, 2004 ©2004 by American Society of Hematology

Adult human HSCs generate significant numbers of hepatocytes in a noninjury fetal model. Graça Almeida-Porada et al. Blood 2004;104: ©2004 by American Society of Hematology

Human hepatocytes generated in vivo from the human hematopoietic stem cells are functional. Graça Almeida-Porada et al. Blood 2004;104: ©2004 by American Society of Hematology

In situ hybridization shows that cells within the vessel walls and biliary ducts are of human origin. Graça Almeida-Porada et al. Blood 2004;104: ©2004 by American Society of Hematology

Different phenotypes of HSC have different characteristics regarding hepatocyte production. Graça Almeida-Porada et al. Blood 2004;104: ©2004 by American Society of Hematology

Human hepatocyte generation in the fetal sheep model is not caused by cell fusion. Graça Almeida-Porada et al. Blood 2004;104: ©2004 by American Society of Hematology