Based on: Glund S et al., Clin Pharmacokinet 2016 Pharmacokinetics of idarucizumab Pharmacokinetics of idarucizumab following administration of idarucizumab.

Slides:



Advertisements
Similar presentations
Proton Pump Inhibitor (PPI) Studies
Advertisements

Area under the plasma concentration time curve. IMPORTANCE OF AUC Pharmacokinetics - measurement of bioavaibility absolute, relative Biopharmaceutics.
Rivaroxaban Has Predictable Pharmacokinetics (PK) and Pharmacodynamics (PD) When Given Once or Twice Daily for the Treatment of Acute, Proximal Deep Vein.
Definition of measurements and patients Michael J. Murphy, et al. Br J Clin Pharmacol 2008;65:
Mega JL, et al. N Engl J Med 2009;360: Genetic Effects on Pharmacokinetic and Pharmacodynamic Responses to Clopidogrel Mega JL, et al. N Engl J.
Morning blood pressure surge (A), HR increase in the morning (B), cfPWV (C), sympathetic BRS (D), and cardiovagal BRS (E) in elderly hypertensive subjects.
Fig. 1.  CsA blood concentration time curve according to the population model (dashed line), the actual measured CsA blood concentrations at t=0, 2 and.
Volume 9, Issue 8, Pages (August 2017)
Trial profile for the pharmacokinetics and pharmacodynamics study in patients with dyslipidaemia (A) and the ambulatory blood pressure study (B) *Participants.
Checklist for Site Reconnaissance (Sabatini et al_2002)
שאילת שאלות מקדמות למידה
Fentanyl HCl iontophoretic transdermal system (ITS): clinical application of iontophoretic technology in the management of acute postoperative pain  I.
Fig. 2. Engraftment of CART-EGFRvIII and cytokine modulation in the peripheral blood. Engraftment of CART-EGFRvIII and cytokine modulation in the peripheral.
Idarucizumab, a Specific Reversal Agent for Dabigatran: Mode of Action, Pharmacokinetics and Pharmacodynamics, and Safety and Efficacy in Phase 1 Subjects 
Pharmacokinetics and pharmacodynamics of oral tolvaptan in patients with varying degrees of renal function  Susan E. Shoaf, Patricia Bricmont, Suresh.
Idarucizumab, a Specific Reversal Agent for Dabigatran: Mode of Action, Pharmacokinetics and Pharmacodynamics, and Safety and Efficacy in Phase 1 Subjects 
IMPRESSION Trial design: Patients presenting with acute MI and undergoing an invasive approach, along with ticagrelor loading dose, were randomized to.
Receiver operating characteristic curves with statistical significance are shown. Receiver operating characteristic curves with statistical significance.
Normalized and averaged images of rGMC and I-123 iomazenil BP
Forest plot of risk ratio with its 95% CI for the incidence of contrast-induced nephropathy among patient taking statin versus control based on renal impairment.
Plasma concentration–time profile, relative bioavailability and pharmacokinetic (PK) parameters of 4 mg TAK-228 in the single-agent QD PK run-in period,
Itraconazole tissue and fluid concentrations in humans as multiples of the maximal or simultaneously measured concentration in plasma (μg/ml) after systemic.
HAVEN 2 Updated Analysis: Multicenter, Open-Label, Phase 3 Study to Evaluate Efficacy, Safety and Pharmacokinetics of Subcutaneous Administration of Emicizumab.
Voriconazole tissue and fluid concentrations in humans as multiples of the maximal or simultaneously measured concentration in plasma (μg/ml) after systemic.
Reciprocal Functions.
ROC for predicted combined death or neurodevelopmental impairment compared with actual death or neurodevelopmental impairment as stratified by gestational.
Kaplan–Meier curves of long-term survival in young (
ROC curve for separating advanced stages (advanced BE and EA) versus early stages (BE or BE instability) using total genome-wide LOH [area under the curve.
Figure Diagrammatic levodopa pharmacokinetics after single doses of immediate release (IR) carbidopa/levodopa (CD/LD) and 3 strengths of extended release.
Effects of E. coli and S. aureus infection on levels of TNF-α and IL-1β in milk. Effects of E. coli and S. aureus infection on levels of TNF-α and IL-1β.
Daily variation in faecal corticosterone concentration expressed as mean values for each group. Daily variation in faecal corticosterone concentration.
Christopher T. Nguyen et al. BTS 2018;3:97-109
Receiver operating characteristic curves for the association of primary outcome using each clinical risk score and each clinical risk score adjusted for.
Baseline Characteristics of Elderly Participants in the Cardiovascular Health Study,According to Quintiles of Cystatin C Michael G.Shlipak et al N Engl.
Comparative receiver operating characteristic (ROC) curves and the area under the curve (AUC) in association with 30-day mortality for severity scores.
Comparison of triglycerides AUC 480’ between IGT+reduced FPIS group, IGT+preserved FPIS group, and IGT+reduced FPIS+reduced FPIS and FPIS restitution with.
Receiver operating characteristic curves (ROC) for the metabolites between the systemic inflammatory response syndrome (n=15) and sepsis (n=35) groups.
(A) ROC for the prediction of 5-year mortality in unoperated significant MR. AUCs and corresponding p values are shown for lateral annulus E/E′ (AUC=0.69,
Mean (SD) AMG 557 serum concentration–time profiles following single-ascending dose (SAD) (A) and multiple-ascending dose (MAD) (B) administration AMG.
Overexpression of BTG2 resulted in an increase in hepatic gluconeogenesis. Overexpression of BTG2 resulted in an increase in hepatic gluconeogenesis. A:
Drug levels during the course of a dosing interval.
Kaplan-Meier survival curves for non-fatal stroke or mortality based on IMRS categories among (A) women (p-trend
Assessment of infarct size by biomarker measurement.
Novel Strategies for Immune Monitoring in Kidney Transplant Recipients
Reduction of muscle soreness after intervention, described as AUC of the difference after intervention minus before intervention for placebo and leucine.
—ROC curves for each simple test compared with NCS (gold standard) plotting the sensitivity versus 1-specificity (the false-positive rate) for different.
Odds of incident diabetes by OGTT insulin patterns according to subjects characterized by presence or absence of IGT or dichotomized at the median value.
Fluconazole tissue and fluid concentrations in humans as multiples of the maximal or simultaneously measured concentration in plasma (μg/ml) after systemic.
Number of outbreaks associated with drinking water by water system type and year (n = 780), 1971 to “Other” includes outbreaks associated with bottled.
Receiver-operating characteristic curves showing the performance of the diabetes risk score in predicting diabetes in the United Arab Emirates (UAE) citizens.
The figure shows the mean±SD of glucose and insulin for the 2-hour OGTTs and MTTs for the 12 HP diet subjects and the 12 HC diets subjects. The figure.
ROC curves showing additive value of DHE in diagnosing ongoing episode of recurrence among all patients with established history of recurrent pericarditis.
Hector H. García et al. Clin. Microbiol. Rev. 2002; doi: /CMR
Rituximab immunotherapy: it’s getting personal
Roberta B. Carey et al. Clin. Microbiol. Rev. 2018; doi: /CMR
Peptide dose-response curves were done to estimate the avidity of these HTL for peptide TARP1-14 (A) and TARP14-27 (B-E) using autologous PBMCs and dendritic.
Immunologic and pharmacokinetic studies.
Structural and population pharmacokinetic properties (single drug) of BRAF indicator dabrafenib, vemurafenib and encorafenib and of MEK indicator trametinib,
Tivantinib behaves as an antimitotic agent.
Kaplan-Meier survival (renal event-free) curves during follow-up by tertiles of plasma copeptin. Kaplan-Meier survival (renal event-free) curves during.
Kaplan–Meier curves for RFS and OS by various marker groups.
Association of overall survival and PAP-specific (A, B) and PA2024-specific (C, D) CTL activity at week 26 using categorical (tertile) analysis and continuous.
Mean percentage change from baseline in total IGF-I and the R1507 serum concentration values following a single i.v. administration of R mg/kg (n.
ROC analysis of MIC-1 and CA19-9.
Flavopiridol inhibits rhabdoid cell survival and induces cell cycle arrest and apoptosis. Flavopiridol inhibits rhabdoid cell survival and induces cell.
Plasma concentration-time profile after oral administration of a single dose. Plasma concentration-time profile after oral administration of a single dose.
(A) Twenty-four-hour plasma profiles of insulin and amylin in healthy subjects. (A) Twenty-four-hour plasma profiles of insulin and amylin in healthy subjects.
Receiver operating characteristic (ROC) curves for discriminating diabetic subjects without retinopathy from control subjects using a logistic regression.
Receiver operator characteristic (ROC) curve for fasting blood glucose (FBG) predicting posttransplantation diabetes (PTD) using time 0 FBG (a) and screening.
Pharmacodynamic and pharmacokinetic evaluation of EXE-RM-LNC in a high-fat diet (HFD)-induced obese/diabetic mouse model following acute treatment. Pharmacodynamic.
Presentation transcript:

Based on: Glund S et al., Clin Pharmacokinet 2016 Pharmacokinetics of idarucizumab Pharmacokinetics of idarucizumab following administration of idarucizumab in middle-aged, elderly, RI: 60–90 and RI: 30–60 subjects AUC: area under the concentration–time curve from zero to infinity RI: renally impaired

Based on: Glund S et al., Clin Pharmacokinet 2016 Pharmacokinetics of idarucizumab Pharmacokinetics of idarucizumab following administration of idarucizumab in middle-aged, elderly, RI: 60–90 and RI: 30–60 subjects

Based on: Glund S et al., Clin Pharmacokinet 2016 Pharmacokinetics of idarucizumab Pharmacokinetics of idarucizumab following administration of idarucizumab in middle-aged, elderly, RI: 60–90 and RI: 30–60 subjects