Antioxidants and prevention of gastric cancer Introduction Oxidative stress can cause cancer. Our aim was to establish whether antioxidants reduce the incidence of gastric cancer. It is an important issue because although the global incidence of gastric cancer has been decreased dramatically in recent decades, Nonetheless, gastric cancer remains a major public health issue as the fourth most common cancer and the second leading cause of cancer death worldwide. Moreover, it is the most common cancer in north and northwest Iran. Methods Results We found that higher dietary intake of vitamin C, vitamin E and β-carotene was inversely associated with gastric cancer risk. Subgroup analyses suggested the effects of these antioxidant vitamins were different in gastric cancer subtypes. While no such association was observed for blood levels of these antioxidant vitamins. No single antioxidant can replace the combination of natural phytochemicals in fruits and vegetables and achieve their health benefits. The evidence suggests that antioxidants are best acquired through whole food consumption, not from expensive dietary supplements Conclusion Fruit and vegetables and their antioxidant contents have protective effects against gastric cancer but single antioxidant vitamin and dietary antioxidant supplements may not have substantial benefits to gastric cancer, thus the results should be interpreted cautiously. Current data were obtained from electronic databases (PubMed and Google Scholar sites. This is a valid study, so we have evaluated the role of antioxidant in gastric cancer when it is used through fruit and vegetables, singly and as supplements. References. 1.Kong P and et al. Vitamin Intake Reduce the Risk of Gastric Cancer: Meta-Analysis and Systematic Review of Randomized and Observational Studies. PloS one. 2014;9(12):e Li P and et al. Association between dietary antioxidant vitamins intake/blood level and risk of gastric cancer. International Journal of Cancer. 2014;135(6): Malekzadeh R, Derakhshan MH, Malekzadeh Z. Gastric cancer in Iran: epidemiology and risk factors. Arch Iran Med. 2009;12(6): Toktam Sahranavard 1, Zahra Kiyanpour 2 1,2-Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences (MUMS), Mashhad, Iran Poster ID: 6198   This work was supported by Razavi Hospital, Razavi Mehr Centre. Acknowledgments