Page 1 Transporter Screening -Profacgen
Page 2 Transporters are a group of specialized membrane proteins that power the translocation of numerous substances, including essential nutrients, ions, neurotransmitters, cellular waste and environmental toxins, across the cellular membrane. Many transporters have emerged as therapeutic targets for diseases such as depression, schizophrenia, cancer, and diabetes. Therefore, transporter screening for therapeutically effective and safe compounds has become very important in the discovery and development of transporter-targeted drugs.
Page 3 Second Page : Profacgen provides specialized transporter panels and customized transporter screening services enabling you to identify novel transporter-targeted compounds. Our transporter panels include FDA transporter screening panel, monoamine transporter models and many other cell models. We employ robust transporter uptake and inhibition assays to perform quick and cost-effective screening of new molecular entities (NMEs) for their interactions with transporters, and offer you results with good signal-to-background ratio and Z ’ scores.
Page 4 Assays: Electrophysiology Radioactive flux detection Fluorescence detection
Page 5 Features: Cell based assays providing functional characterization of compound activity Coverage of key transporters Availability of various panels Short turn-around time Customized screening project design
Page 6 Contact Profacgen website: service.htmhttps:// service.htm