The Best Selling Chemicals at BOC Sciences BOC Sciences provides a wide scope of chemicals and related custom services. In 2016, the company made a lot.

Slides:



Advertisements
Similar presentations
Antiulcer drugs.
Advertisements

Carl B. Goodman, Ph.D. Professor Pharmacology College of Pharmacy & Pharmaceutical Sciences Florida A&M University 308E FSH-SRC
The molecular formula is C 5 H 8. What is the structure?
Supplementary Fig. 1. Enlarged images of cellular structures in 3D cultures. Spheroids (A) and filamentous outgrowths (B) in presence of 50 ng/ml BMP7.
. Cell Division- Regulation of the Cell Cycle. Target #25-I can explain the external factors that are involved in cell cycle regulation Both external.
Principles of Pharmacology
Isosteviol derivatives induced apoptosis in Human lung cancer via targeting MEK/MAPK pathway: An in vitro and in vivo study Ahmed M Malki 1,,PhD Stephen.
Adrenergic Receptor Antagonists Excessive sympathetic activity is characteristic of a number of pathological states including: Hypertension Angina pectoris.
IN CANCER MOLECULAR DETECTION. WHAT DO THEY DETECT? Specific proteins Expression of certain genes Mutations Epigenetic Changes.
TIDEA Target (and Lead) Independent Drug Enhancement Algorithm.
Nehad A. El Sayed, Amal A. H. Eissa, Reem K. Arafa and Ghada F. El Masry* Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University.
F A C U L T Y O F H E A L T H A N D M E D I C A L S C I E N C E S U N I V E R S I T Y O F C O P E N H A G E N Discovery of potent inhibitors of the epigenetic.
Page 1 Assay kitAssay kit in Creative BioMart —by Creative BioMart.
Loratadine Loratadine is a histamine H1 receptor antagonist, used to treat allergies. Also acts as a selective inhibitor of B(0)AT2 with IC50 of 4 μM.
Benign Prostatic Hyperplasia: Trends in Medical Management
International Neurourology Journal 2014;18:
Telephone    Provider of Global Contract Research Services Accelerating Preclinical Research, Drug Discovery.
Volume 43, Issue 5, Pages (May 2003)
Drugs acting on the uterus
Featured Inhibitors for October-BOC Sciences
Antibody Drug Conjugates Services Antibody-drug conjugates Antibody-drug conjugates (ADCs) are a very important class of highly potent drugs designed as.
GSK126 - CAS GSK126GSK126 is a potent, highly selective, S-adenosyl-methionine- competitive, small-molecule inhibitor of EZH2 methyltransferase.
Molecular Therapy - Nucleic Acids
Volume 11, Issue 8, Pages (August 2004)
Cellular Respiration (Aerobic).
Choose and Use Your Chemical Probe Wisely to Explore Cancer Biology
Cyclin-Dependent Kinase 2 Promotes Tumor Proliferation and Induces Radio Resistance in Glioblastoma  Jia Wang, Tong Yang, Gaofeng Xu, Hao Liu, Chunying.
Photoactivated 1,3-Dipolar Cycloaddition: Scope and Applications
Inhibitor of MAP kinase activation blocks colon cancer growth
Volume 43, Issue 5, Pages (May 2003)
c-Kit as a Novel Potential Therapeutic Target in Colorectal Cancer
Small-molecule inhibitor QLT-0267 suppresses ILK activity and inhibits its downstream signaling. Small-molecule inhibitor QLT-0267 suppresses ILK activity.
IR Spectrum Data Analysis
Figure 4 Possible combination therapies CDK4/6 inhibitors
The cellular immune response to cancer is complex and involves a diverse repertoire of immunoregulatory interactions principally involving antigen presenting.
How Medicines Work: Stimulation and Inhibition
SB Size: 10 mg M.W.= Batch No.: 1A/ Description:
INTERLEUKIN 10 (IL-10) CATEGORY: RECEPTORS & MOLECULES
Volume 19, Issue 8, Pages (August 2017)
Figure 2 from Sancho et al.
The cancer stem cell concept in cancer progression and metastasis
The putative genomic evolution of prostate cancer from normal epithelium to castrate-resistant, metastatic cancer Figure 2 from Mitchell and Neal British.
Notes Cell Communication & Cell Signaling!
Volume 18, Issue 4, Pages (October 2010)
Molecular features of the colon during homeostasis and carcinogenesis
Figure 1 from T Schenk et al.
The RAF Inhibitor Paradox Revisited
Choose and Use Your Chemical Probe Wisely to Explore Cancer Biology
Histone H3.3 Mutations: A Variant Path to Cancer
In melanoma tumours expressing the BRAFV600E oncogene RAF inhibitor treatment decreases ERK activation resulting in tumour regression and increased survival.
Volume 19, Issue 9, Pages (September 2012)
Spectrum of cellular processes regulated by AXL activity
Volume 20, Issue 11, Pages (November 2013)
Volume 22, Issue 5, Pages (November 2012)
Molecular Characterization of Acquired Resistance to the BRAF Inhibitor Dabrafenib in a Patient with BRAF-Mutant Non–Small-Cell Lung Cancer  Charles M.
Mutant BRAF Melanomas—Dependence and Resistance
The Elements of Translational Chemical Biology
Photo-switch Protein 1.
Pro-proliferative effect of lipoxin A4 (LXA4) is phosphatidylinositol 3′-kinase dependent and mediated by ALX/formyl peptide L1 receptor. 100 nM LXA4 promoted.
Small-molecule EZH2 inhibitor development.
MDA-468TR-PTEN (with and without 100 ng/ml doxycycline) and MDA-468TR-vector (with dox) were serum starved overnight and the following day treated for.
GS87 is a highly specific and potent GSK3 inhibitor that induces AML cell differentiation. GS87 is a highly specific and potent GSK3 inhibitor that induces.
Cytotoxic effect of BET inhibition in malignant B-cell lines and CLL patient-derived B cells is independent of survival signals. Cytotoxic effect of BET.
Research Rational Drug Design: A process for drug design which bases the design of the drug upon the structure of its protein target. Structural mapping.
MAPK/ERK signaling regulates TLR4 gene expression in response to BRAFV600E. MAPK/ERK signaling regulates TLR4 gene expression in response to BRAFV600E.
Volume 23, Issue 12, Pages (December 2016)
Volume 25, Issue 2, Pages e11 (February 2018)
Tackling Resistance to PI3K Inhibition by Targeting the Epigenome
Presentation transcript:

The Best Selling Chemicals at BOC Sciences BOC Sciences provides a wide scope of chemicals and related custom services. In 2016, the company made a lot of progress in their chemical variety and online display. Here presents several best sellers after the updates we made.

Plx4720 PLX4720 is a 7-azaindole derivative that inhibits B-Raf(V600E) with an IC(50) of 13 nM, defines a class of kinase inhibitor with marked selectivity in both biochemical and cellular assays. PLX4720 preferentially inhibits the active B-Raf(V600E) kinase compared with a broad spectrum of other kinases, and potent cytotoxic effects are also exclusive to cells bearing the V600E allele.

GSK126 is a potent, highly selective, S-adenosyl-methionine-competitive, small- molecule inhibitor of EZH2 methyltransferase activity. GSK126 decreases global H3K27me3 levels and reactivates silenced PRC2 target genes. Gsk126

Metoprolol Tartrate Metoprolol Tartrate is a cardioselective β-adrenergic receptor blocker with IC50 of 42 ng/mL.

Alfuzosin Alfuzosin HCl is an alpha1 receptor antagonist used to treat benign prostatic hyperplasia (BPH).

Misoprostol Misoprostol is a cytoprotective prostaglandin PGE1 analogue. Molecular Weight Molecular Formula C22H38O5

Misoprostol Misoprostol is a cytoprotective prostaglandin PGE1 analogue. Molecular Weight Molecular Formula C22H38O5