Activation of HER4 by heparin ‐ binding EGF ‐ like growth factor stimulates chemotaxis but not proliferation by Klaus Elenius, Subroto Paul, Genève Allison,

Slides:



Advertisements
Similar presentations
by Kevin J. Paavola, Harwin Sidik, J
Advertisements

Negative regulation of cell cycle by intracellular signals Checkpoint p53 detects DNA damage & activates p21 p21 inhibits cdk2-cyclinA Intracellular Regulation.
The oligodendrocyte precursor mitogen PDGF stimulates proliferation by activation of αvβ3 integrins by Wia Baron, Sanford J. Shattil, and Charles ffrench.
Integrin-EGFR Cross-Activation Elizabeth Brooks Department of Chemical Engineering University of Massachusetts, Amherst Peyton Lab Group Meeting December.
Calmodulin controls the rod photoreceptor CNG channel through an unconventional binding site in the N ‐ terminus of the β ‐ subunit by Dietmar Weitz, Martin.
Reconstruction of nuclear receptor network reveals that NR2E3 is a novel upstream regulator of ESR1 in breast cancer by Yun ‐ Yong Park, Kyounghyun Kim,
Transcriptional targets shared by estrogen receptor ‐ related receptors (ERRs) and estrogen receptor (ER) α, but not by ERβ by Jean ‐ Marc Vanacker, Katarina.
Phosphorylation by casein kinase 2 induces PACS ‐ 1 binding of nephrocystin and targeting to cilia by Bernhard Schermer, Katja Höpker, Heymut Omran, Cristina.
Ca 2+ ‐ independent insulin exocytosis induced by α ‐ latrotoxin requires latrophilin, a G protein ‐ coupled receptor by Jochen Lang, Yuri Ushkaryov, Alfonso.
Formation of a nucleoprotein complex containing Tn7 and its target DNA regulates transposition initiation by Zachary Skelding, Robert Sarnovsky, and Nancy.
Molecular aging and rejuvenation of human muscle stem cells by Morgan E. Carlson, Charlotte Suetta, Michael J. Conboy, Per Aagaard, Abigail Mackey, Michael.
Transgenic tobacco expressing a foreign calmodulin gene shows an enhanced production of active oxygen species by Scott A. Harding, Suk ‐ Heung Oh, and.
TGFβ-Receptor 1/ALK5 NEIL MEHTA BIOL
Modulation of NF ‐ κB ‐ dependent transcription and cell survival by the SIRT1 deacetylase by Fan Yeung, Jamie E Hoberg, Catherine S Ramsey, Michael D.
SIP, a novel ankyrin repeat containing protein, sequesters steroid receptor coactivators in the cytoplasm by Ying Zhang, Hua Zhang, Jing Liang, Wenhua.
Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR ‐ bound and RBR ‐ free complexes by Zoltán Magyar, Beatrix Horváth, Safina.
The interaction between uPAR and vitronectin triggers ligand ‐ independent adhesion signalling by integrins by Gian Maria Sarra Ferraris, Carsten Schulte,
Beneficial compaction of spinal cord lesion by migrating astrocytes through glycogen synthase kinase ‐ 3 inhibition by Francois Renault ‐ Mihara, Hiroyuki.
Bringing next ‐ generation diagnostics to the clinic through synthetic biology by Alexis Courbet, Eric Renard, and Franck Molina EMBO Mol Med. Volume ():e
Mutations in XPB and XPD helicases found in xeroderma pigmentosum patients impair the transcription function of TFIIH by Frédéric Coin, Etienne Bergmann,
Defining Epidermal Growth Factor Receptor exon 20 mutant sensitivity to tyrosine kinase inhibition Danny Rayes.
Lung Cancer Tumour Markers
Hepatocyte growth factor in renal failure: Promise and reality
Defining Epidermal Growth Factor Receptor exon 20 mutant sensitivity to tyrosine kinase inhibition Danny Rayes.
Intercellular Communication
Effects of pleiotrophin, a heparin-binding growth factor, on human primary and immortalized chondrocytes  Dr. T. Pufe, Ph.D., G. Groth, M.B. Goldring,
(A) Programmed cell death ligand-1 (PD-L1) expression score was significantly higher in pulmonary adenocarcinomas with grade G2/G3 differentiation as compared.
Sequence alignment of C-terminal phosphorylated plant aquaporins
Hepatocyte growth factor in renal failure: Promise and reality
Notch1 and its role in pre-T-cell acute lymphoblastic leukemia (T-ALL)
Figure 1 A schematic representation of the HER2 signalling pathway
T cell receptor Vβ (TCR-Vβ) expression in a drug-specific T cell line (TCL) and specificity assay of a TCL of patient P1. T cell receptor Vβ (TCR-Vβ) expression.
p53 and Apoptosis: It's Not Just in the Nucleus Anymore
Volume 116, Issue 5, Pages (May 1999)
Figure 1 Specificity of the various epidermal growth factor (EGF)
Uncovering a Tumor Suppressor for Triple-Negative Breast Cancers
Volume 142, Issue 4, Pages (August 2010)
Michael Downes, Christopher Liddle  Cell Metabolism 
JAK3 Specific Kinase Inhibitors: When Specificity Is Not Enough
Figure 3 Localization of ErbB receptors and ligands within the nephron
Nat. Rev. Nephrol. doi: /nrneph
Nat. Rev. Gastroenterol. Hepatol. doi: /nrgastro
Oxidative Modification of Leukocyte Adhesion
T Cells Are Smad’ly in Love with Galectin-9
STING stimulation in T cells inhibits cell cycle progression.
TIMP-2 Mediated Inhibition of Angiogenesis
Volume 92, Issue 6, Pages (March 1998)
Astrocytes: Powering Memory
Insider Influence on ErbB Activity
A New Class of Phytoestrogens
Structure and receptor-binding properties of SCH-C.
Volume 24, Issue 14, Pages R658-R659 (July 2014)
Specific inhibition of Ras, but not Rac, inhibits EGF-stimulated protrusion. Specific inhibition of Ras, but not Rac, inhibits EGF-stimulated protrusion.
Fig. 5. Receptor tyrosine kinase activation in response to growth factor stimulation. Receptor tyrosine kinase activation in response to growth factor.
The new kid on the block(ade) of the IGF-1 receptor
Friends with Benefits: Microenvironmental NRG1β and HGF Mediate HER2-Targeted Resistance in L-HER2+ and HER2E Breast Cancer  Sarah B. Crist, Cyrus M.
CD151-knockdown cells show an aberrant spreading response to PMA
A new key in breast cancer metastasis
Volume 2, Issue 2, Pages (August 2002)
coTCRcys-transduced T cells control tumor growth in vivo.
Down-regulation of the erbB-2 receptor by trastuzumab decreases Akt kinase activation but not MAPK activation. Down-regulation of the erbB-2 receptor by.
ONC201 activates an ISR, decreases cyclin D1 expression, and causes an accumulation of cells in G1 in TNBC cells sensitive to the compounds' antiproliferative.
Potential model of HMQ1611 inhibiting breast cancer cell proliferation
Met is expressed in Her2-overexpressing cell lines and Her2 (+) breast tumors. Met is expressed in Her2-overexpressing cell lines and Her2 (+) breast tumors.
A, effect of TMPP on the binding of 125I-labeled VEGF to endothelial cells transfected with the VEGF receptor. A, effect of TMPP on the binding of 125I-labeled.
Fig. 6 The combined therapeutic efficacy of N-pepABS and low dose of Dox on MDA-MB-231 xenografts. The combined therapeutic efficacy of N-pepABS and low.
Regulation of signaling by wild-type and oncogenic Ras.
RANK ligand and osteoprotegerin in myeloma bone disease
Tackling Resistance to PI3K Inhibition by Targeting the Epigenome
Model of the change in receptor structure on engagement of the ligand IFN-γ. Model of the change in receptor structure on engagement of the ligand IFN-γ.
Presentation transcript:

Activation of HER4 by heparin ‐ binding EGF ‐ like growth factor stimulates chemotaxis but not proliferation by Klaus Elenius, Subroto Paul, Genève Allison, Jilin Sun, and Michael Klagsbrun EMBO J. Volume 16(6): March 15, 1997 ©1997 by European Molecular Biology Organization

Cross ‐ linking of [125I]HB ‐ EGF to cells expressing HER1, HER2, HER3 or HER4 alone. Klaus Elenius et al. EMBO J. 1997;16: ©1997 by European Molecular Biology Organization

Cross ‐ linking of [125I]HB ‐ EGF, [125I]EGF or [125I]ARIA ‐ 1 to cells expressing HER1 or HER4. Klaus Elenius et al. EMBO J. 1997;16: ©1997 by European Molecular Biology Organization

Scatchard analysis of [125I]EGF, [125I]HB ‐ EGF and [125I]HRG–β1 binding to NIH 3T3 cells expressing HER1 or HER4. Klaus Elenius et al. EMBO J. 1997;16: ©1997 by European Molecular Biology Organization

Tyrosine phosphorylation of EGF receptors in cells expressing HER1 or HER4. Klaus Elenius et al. EMBO J. 1997;16: ©1997 by European Molecular Biology Organization

Tyrosine phosphorylation of EGF receptors in MDA ‐ MB ‐ 453 cells. Klaus Elenius et al. EMBO J. 1997;16: ©1997 by European Molecular Biology Organization

Tyrosine phosphorylation of EGF receptors in rat astrocytes. Klaus Elenius et al. EMBO J. 1997;16: ©1997 by European Molecular Biology Organization

Proliferation of cells expressing HER1 or HER4 in response to growth factors. Klaus Elenius et al. EMBO J. 1997;16: ©1997 by European Molecular Biology Organization

Dose ‐ dependent chemotaxis of cells expressing HER1 or HER4. Klaus Elenius et al. EMBO J. 1997;16: ©1997 by European Molecular Biology Organization

Ligand ‐ stimulated PI3 ‐ K activity. Klaus Elenius et al. EMBO J. 1997;16: ©1997 by European Molecular Biology Organization

Wortmannin inhibition of chemotaxis. Klaus Elenius et al. EMBO J. 1997;16: ©1997 by European Molecular Biology Organization