Signal transduction. General scheme There are two general types of receptors: cell-surface and intracellular receptors.

Slides:



Advertisements
Similar presentations
Chapter 16 Cell Communication
Advertisements

Medical Biochemistry Membranes: Membrane receptors; G-proteins Lecture 73 Membranes: Membrane receptors; G-proteins Lecture 73.
Cell Communication Chapter 11. Types of Cell Signaling  Local Regulators – molecules released travel short distances to other cells in the area  Examples:
CHAPTER 9 LECTURE SLIDES
Cell Communication Chapter 9. 2 Fig Fig. 9.2.
11.2 Reception: A signaling molecule binds to a receptor protein, causing it to change shape A receptor protein on or in the target cell allows the cell.
Signal Transduction Pathways
Signal Transduction Pathways Pratt & Cornely, Chapter 10.
Warm-Up Why do you communicate? How do you communicate?
Basic Concepts of Metabolism
By the end of this lecture you will be able to :  Classify receptors into their main superfamilies  Identify the nature & time frame of their response.
B. Signal Transduction Pathway (cell signaling)
Cell Communication Chapter 9. Please note that due to differing operating systems, some animations will not appear until the presentation is viewed in.
Warm-Up  Why do you communicate?  How do you communicate?  How do you think cells communicate?  Do you think bacteria can communicate? Explain.
By Prof. Omnia Nayel Assoc. Prof. Osama Yousif. By the end of this lecture you will be able to :  Classify receptors into their main superfamilies 
Cytokines, Growth Factors and Hormones SIGMA-ALDRICH.
By the end of this lecture you will be able to :  Classify receptors into their main superfamilies  Identify the nature & time frame of their response.
CHAPTER 11 CELL COMMUNICATION 1. WHAT YOU SHOULD KNOW: The 3 stages of cell communication: reception, transduction, and response. How G-protein-coupled.
Chapter 5.
بسم الله الرحمن الرحيم Cell Physiology. Exit Home BASIM ZWAIN LECTURE NOTES BASIM ZWAIN LECTURE NOTES.
Communication- signal pathways Distinguish among types of cell-to-cell communication List the four classes of membrane receptors. Explain how receptors.
Cell Communication Chapter Cell Communication: An Overview  Cells communicate with one another through Direct channels of communication Specific.
Cell Communication Chapter 11.
Signal Transduction Pathways
Caffeine Signaling via Ligand-Receptor Binding Agonist - ligand binding to a receptor and eliciting a response Antagonist - ligand binding to a receptor.
Cell Communication Chapter 9.
By Prof. Omnia Nayel Assoc. Prof. Osama Yousif. By the end of this lecture you will be able to :  Classify receptors into their main superfamilies 
Chapter 14. Signal Transduction Signal transduction is the process by which an extracellular signal alters intracellular events. 1. First and second messengers.
Cell Communication Chapter 9.
MAIN IDEAS CHAPTER 11: 1. Cell communication processes share common features that reflect a shared evolutionary history. 2. Cells communicate with each.
Cell Communication Chapter 9. 2 Cell Communication Communication between cells requires: ligand: the signaling molecule receptor protein: the molecule.
You Must Know  3 stages of cell communication Reception, transduction, & response  How G-protein-coupled receptors receive cell signals & start transduction.
AP Biology Cell Communication CHAPTER 11. Warm-Up 1. Why do you communicate? 2. How do you communicate? 3. How do you think cells communicate? 4. Do you.
Cell Communication Chapter 9. 2 Cell Communication Communication between cells requires: ligand: the signaling molecule receptor protein: the molecule.
Chapter 11~ Cell Communication 2xnwU Pohttp://youtu.be/U6uHotlXv Po Real action in the body
Bruno Sopko.  Signal Transduction Pathways  Organization  Signals  Receptors ◦ Soluble Receptors ◦ Transmembrane Receptors  Enzyme Coupled Receptors.
Signal transduction The process of converting extracellular signals into cellular responses. extracellular signaling molecules (ligands) synthesized and.
LECTURE PRESENTATIONS For CAMPBELL BIOLOGY, NINTH EDITION Jane B. Reece, Lisa A. Urry, Michael L. Cain, Steven A. Wasserman, Peter V. Minorsky, Robert.
Cell Communication Chapter 9. Cell Communication Communication between cells requires: ligand: the signaling molecule receptor protein: the molecule to.
An Introduction to Medicinal Chemistry 3/e PROTEINS AS DRUG TARGETS:
Warm-Up Why do you communicate? How do you communicate?
3.D.3 Signal Transduction Signal transduction pathways link signal reception with cellular response.
Cell Communication Chapter 11.
Warm-Up Why do you communicate? How do you communicate?
Hormones and Signal Transduction
Warm-Up Why do you communicate? How do you communicate?
Chapter 11 – Cell Communication
Signals and Responses Cell Communication.
SIGNAL TRANSDUCTION Signal Transduction Pathway Protein Modification Phosphorylation Cascade Protein Kinases.
Concept 4: Analyzing Cell Communication
Warm-Up Why do you communicate? How do you communicate?
Chapter 11~ Cell Communication
Chapter 11 Cell Communication.
Basics of Signal Transduction
Chapter 11~ Cell Communication
Intracellular Receptors
Cell to Cell Communication via Enzyme Linked Receptors
Cell Communication Chapter 6.
Cell Communication.
Chapter 11 Cell Communication.
Cell Communication CHAPTER 11.
Chapter 11~ Cell Communication
Warm-Up Why do you communicate? How do you communicate?
Cell Communication Chapter 11.
Warm-Up Why do you communicate? How do you communicate?
Warm-Up Why do you communicate? How do you communicate?
Nat. Rev. Endocrinol. doi: /nrendo
Warm-Up Why do you communicate? How do you communicate?
Warm-Up Why do you communicate? How do you communicate?
Review Quiz Please open this review in a slide show mode. Answer a question first, then go to the next slide for the correct answer.
Presentation transcript:

Signal transduction

General scheme

There are two general types of receptors: cell-surface and intracellular receptors

Examples of hormones that act through intracellular receptors

Signal transduction through intracellular receptors

Signal transduction through cell-surface receptors

G-PROTEIN-COUPLED RECEPTORS (HEPTAHELICAL, GPCR)

Epinephrine activates G-protein- coupled receptor

cAMP formation and breakdown

Targets of protein kinase A (PKA)

G-protein activation and self- inactivation

Some toxins cause modification of G- proteins

Second messengers cAMP and cGMP Calcium (Ca 2+ ) IP3 (inositol-triphosphate)

One of the reasons for complexity of signal transduction pathways

Hormones that use cAMP as second messenger

RECEPTOR TYROSINE KINASES

Growth factor signalling pathway

Usually each receptor is connected to more than one signalling pathways Insulin: -Gene expression

Insulin: gene expression

Insulin: enzymes activation

TYROSINE KINASES AND CANCER

Constitutive receptor activation

Receptor tyrosine kinase inhibitors

DOMAIN STRUCTURE OF PROTEINS THAT PARTICIPATE IN SIGNAL TRANSDUCTION

Example of real pathway that regulates actin rearrangement

Feedback: Privacy Policy Feedback
Do Not Sell My Personal Information
About project: SlidePlayer Terms of Service

© 2025 SlidePlayer.com. Inc. All rights reserved.