Normal stomach. Fundic mucosa with parietal & chief cells Antral mucosa with mucin secreting glands Stomach - Histology.

Slides:

Advertisements

Similar presentations

Upper GI quiz PBL 28.

Advertisements

Experimentally induced gastric ulcer in the rat MUDr. Michal Jurajda.

Helicobacter pylori infection and its consequences.

Gastrointestinal System

GASTRITIS ULCER DISEASE

Faculty of Allied Medical Sciences Histopathology and Cytology (MLHC-201)

Peptic Ulcer Disease Dr Maha Arafah. Objectives Upon completion of this lecture the students will : A] Understand the Pathophysiology of acute and chronic.

STOMACH Cell types: Mucosal surface & foveolae:  Surface foveolar cells - secrete mucous Mucous neck cells - progenitor cells  Glands: Mucous cells.

PATHOLOGY AND PATHOGENESIS OF PEPTIC ULCER

PEPTIC ULCER disease (PUD) Dr. Gehan Mohamed Dr. Abdelaty Shawky.

Gastrointestinal pathology Part III

© 2004 Current Medicine Group Ltd FISIOLOGÍA DIGESTIVA (BCM II) Clase 7: Gastritis y H. pylori Dr. Michel Baró A.

بسم الله الرحمن الرحيم GIT Diseases By Dr. Ghada Ahmed Lecturer of Pathology Benha Faculty of Medicine.

Peptic Ulcer Disease. Peptic ulcer  refers to erosion of the mucosa lining any portion of the G.I. tract.  It is defined as : A circumscribed ulceration.

Histology of the upper Git

Diseases of Stomach Aim: to understand the pathogenesis of gastritis, peptic ulcer disease and cancer of stomach. 1.

PEPTIC ULCER. Ulcers are defined as a breach in the mucosa of the alimentary tract, which extends through the muscularis mucosa into the submucosa or.

Diseases of The Stomach Prof: Hussien Gadalla. Gastric Disorders Acute Gastritis Chronic Gastritis Peptic Ulcer Disease These three are common and related.

Non-neoplastic Stomach Vinay Prasad, MD Nationwide Children’s Hospital Narrated by Dr. Ben Swanson.

Upper Gastrointestinal Diseases. Upper GI Diseases Esophagus Stomach Duodenum.

Inflammation and repair Dr Shaesta Naseem

Gastrointestinal Block Pathology lecture Nov 20, 2012 Dr. Maha Arafah Dr. Ahmed Al Humaidi Peptic Ulcer Disease.

GI Tutorial. General Structure Mucosa –Epithelium –Lamina Propria –Muscularis Mucosa Submucosa –Connective tissue, blood vessels, nerve plexus Muscularis.

NEOPLASMS OF THE STOMACH

Digestive pathology I. Chronic peptic ulcer From: Stevens A. J Lowe J. Pathology. Mosby 1995 Fig Deep loss of substance, often single, round or.

Gastric carcinoma.

Chapter 8 The diseases of digestive system

PEPTIC ULCER DISEASE (PUD)

Pathology of the Stomach. Objectives and aim To learn the congenital disorders of the stomach To learn the congenital disorders of the stomach To learn.

Inflammation and repair Pathology Practical class

By Dr. Gehan Mohamed Dr. Abdelaty Shawky

Peptic Ulcer Disease Dr Maha Arafah.

classification of acute inflammation : according to the inflammatory fluid exudates, -Exudates are any fluid that filters from the circulatory system.

Gastrointestinal system SYLLABUS: RBP(Robbins Basic Pathology) Chapter: The Oral Cavity and the Gastrointestinal Tract.

PEPTIC ULCER DISEASE (PUD) By Dr. Abdelaty Shawky Assistant professor of pathology 1.

Chronic Gastritis and Gastric Cancer

위암병리보고서의 기재사항 서울대학교 김 우 호.

Case 1 현 O 훈 (M/34). Diagnosis : Stomach, distal gastrectomy: Signet ring cell carcinoma 1) Location: Angle 2) Tumor gross type: Early.

Kyung Hee University, Seoul, Korea GI Conference UGI Conference Presented by Byeong-Joo Noh Supervised by Youn-Wha Kim Kyung Hee University, Seoul, Korea.

Case 1. Diagnosis : Stomach, resection margin, proximal, FS-1, biopsy: No tumor Stomach, resection margin, distal, FS-2, biopsy: Adenocarcinoma Lymph.

Acute Gastritis.

Gastrointestinal pathology esophagus and stomach lecture 2

GI For Rehabilitation.

ESOPHAGEAL CARCINOMA There are two types: squamous cell carcinomas and adenocarinomas. Worldwide, squamous cell carcinomas constitute 90% of esophageal.

Peptic Ulcer Disease Thomas Rosenzweig, MD.

Peptic Ulcers The histologic appearance varies with the activity, chronicity, and degree of healing. In a chronic, open ulcer, four zones can be distinguished.

Diseases of Vermiform Appendix

Gastric carcinoma.

Volume 24, Issue 3, Pages (September 2017)

GI Pathology Lab Dr Heyam.

Pleomorphic adenoma –the tumour at the left side is white gray firm lobulated mass without hemorrhage or necrosis. note the normal lobulated gland at the.

By Dr. Abdelaty Shawky Assistant professor of pathology

GIT BLOCK PATHOLOGY PRACTICAL Dr Abdullah Basabein

Volume 24, Issue 3, Pages (September 2017)

GI Pathology I, Case 3 37-year-old man presents with epigastric pain relieved by eating. Stool is positive for occult blood.

CH 23 Anatomy of the Stomach James F. Thompson, Ph.D.

GASTRITIS By : BILAL HUSSEIN.

Care of Patients with Stomach Disorders

STOMACH CANCER BY DR: ALI ALWAILY/MD.

Gastrointestinal Pathology I

Dr. Maha Arafah Dr. Ahmed Al Humaidi

Pathology and pathophsiolgy of peptic ulcer

GERD and Peptic ulcer Lab

Presentation transcript:

Normal stomach

Fundic mucosa with parietal & chief cells Antral mucosa with mucin secreting glands Stomach - Histology

TOPICS GASTRITIS H. PYLORI PEPTIC ULCER DISEASE GASTRIC CANCER

GASTRITIS CLASSIFICATION Acute vs Chronic Topographic Etiologic GRADING Mild, Moderate, Severe

Sydney system – Classification: Chronic gastritis Fig.: Dixon MF, Genta RM, Yardley JH, Correa P. Classification and grading of gastritis. The updated Sydney System. International Workshop on the Histopathology of Gastritis, Houston Am J Surg Pathol Oct;20(10):

H. PYLORI GASTRITIS Epidemiology Morphology Mode of infection Pathogenicity

H. pylori Lymphoid follicle Inflammatory infiltrate Atrophic glands

1. H.Pylori

H. PYLORI GASTRITIS Types of gastritis Peptic ulcer disease Disease progression Associated tumors

GASTRIC & DUODENAL ULCERS Acute vs Chronic

ACUTE GASTRIC ULCERS Tend to be multiple No predilective sites Etiologic Associations

Hemorrhagic erosions Érosions Erosions Ulcers

Intact epithelium Superficial erosion Fibrinoinflammatory exudate Diffuse erosion Inflammatory Infiltrate Intact epithelium Hémorrhage

PEPTIC ULCERS Common Sites Usually single but can be multiple Strong association with H.P. Histology: - 4 layers

Peptic ulcer (stomach) Esophagu s Ulcer Stomach

Peptic ulcer (stomach) Macroscopic appearance : « punched-out » + convergence of gastric folds

Peptic ulcer (stomach) Ulcer penetrating just inside the muscularis propria Overhanging margins

Peptic ulcer (stomach)

Peptic ulcer (duodenum) Ulcer

PEPTIC ULCERS Histology: 4 layers Fibrinous exudate Polymorphs Granulation tissue Fibrosis

Peptic ulcer (stomach) Mucosal ulceration

Ulcer Intact gastric mucosa (with overhanging margin) Peptic ulcer (stomach)

Granulation tissue Peptic ulcer (stomach) FibrosisDebris + Acute inflammation

Peptic ulcer (stomach)

COMPLICATIONS OF PEPTIC ULCERS Hemorrhage Obstruction Penetration Perforation Carcinoma

GASTRIC CANCER CLASSIFICATION Early vs Advanced Gross Appearance Histologic

Gastric adenocarcinoma : Macroscopic Aspect Early cancer: Advanced cancer: The various morphologies of gastric adenocarcinoma

Gastric adenocarcinoma: intestinal type Ulcered tumor Early antral tumor

Gastric adenocarcinoma Ulcerated tumor with irregular surface

Gastric adenocarcinoma: diffuse type “Linitis plastica” Diffuse wall thickening

Gastric adenocarcinoma gastrique Intestinal type adenocarcinoma, moderately differentiated Fibrinopurulent exudate (ulceration) Infiltrative irregular glands

Gastric adenocarcinoma Intestinal type adenocarcinoma Desmoplastic reaction Invasive glands

Gastric adenocarcinoma Invasive glands Luminal necrosis Intestinal type adenocarcinoma

Gastric adenocarcinoma Diffuse type adenocarcinoma (signet ring cell carcinoma) « Signet ring cells » Surface epithelium (normal)

T staging

N staging

Gastric adenocarcinoma Tumor with peritoneal invasion & peritoneal carcinomatosis