Elastin Stabilizes an Infarct and Preserves Ventricular Function by Tomohiro Mizuno, Terrence M. Yau, Richard D. Weisel, Chris G. Kiani, and Ren- Ke Li.

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Presentation transcript:

Elastin Stabilizes an Infarct and Preserves Ventricular Function by Tomohiro Mizuno, Terrence M. Yau, Richard D. Weisel, Chris G. Kiani, and Ren- Ke Li Circulation Volume 112(9 suppl):I-81-I-88 August 30, 2005 Copyright © American Heart Association, Inc. All rights reserved.

Figure 1. Left ventricular function, evaluated by echocardiography. Tomohiro Mizuno et al. Circulation. 2005;112:I-81-I-88 Copyright © American Heart Association, Inc. All rights reserved.

Figure 2. Left ventricular function, evaluated in a Langendorff apparatus. Tomohiro Mizuno et al. Circulation. 2005;112:I-81-I-88 Copyright © American Heart Association, Inc. All rights reserved.

Figure 3. The scar dimensions and left ventricular dimensions evaluated by echocardiography. Tomohiro Mizuno et al. Circulation. 2005;112:I-81-I-88 Copyright © American Heart Association, Inc. All rights reserved.

Figure 4. The scar size (A) and left ventricular volumes (B) evaluated by planimetry. Tomohiro Mizuno et al. Circulation. 2005;112:I-81-I-88 Copyright © American Heart Association, Inc. All rights reserved.

Figure 5. Evaluation of transgene expression of the recombinant elastin in vitro (A) and in vivo (B) by Western blotting. Tomohiro Mizuno et al. Circulation. 2005;112:I-81-I-88 Copyright © American Heart Association, Inc. All rights reserved.

Figure 6. Staining of the transplanted endothelial cells and the recombinant elastin. Tomohiro Mizuno et al. Circulation. 2005;112:I-81-I-88 Copyright © American Heart Association, Inc. All rights reserved.

Figure 7. Elastin deposition in the scar. Tomohiro Mizuno et al. Circulation. 2005;112:I-81-I-88 Copyright © American Heart Association, Inc. All rights reserved.

Figure 8. Elastin deposition throughout the scar and border zone, 1 month after cell transplantation (elastic von-Giesson staining). Tomohiro Mizuno et al. Circulation. 2005;112:I-81-I-88 Copyright © American Heart Association, Inc. All rights reserved.