Multiple roles of the coagulation protease cascade during virus infection by Silvio Antoniak, and Nigel Mackman Blood Volume 123(17):2605-2613 April 24,

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Presentation transcript:

Multiple roles of the coagulation protease cascade during virus infection by Silvio Antoniak, and Nigel Mackman Blood Volume 123(17): April 24, 2014 ©2014 by American Society of Hematology

The coagulation cascade and PAR1 and PAR2 enhance HSV infection of endothelial cells. Silvio Antoniak, and Nigel Mackman Blood 2014;123: ©2014 by American Society of Hematology

Binding of FX to Adv5 increases infection of hepatocytes and enhances activation of macrophages. Silvio Antoniak, and Nigel Mackman Blood 2014;123: ©2014 by American Society of Hematology

PAR2 modulates TLR signaling in human epithelial cell lines. Silvio Antoniak, and Nigel Mackman Blood 2014;123: ©2014 by American Society of Hematology

PAR1 and PAR2 modulate TLR3-dependent expression of IFN-β in CFs. CVB3 infection of CFs leads to the release of ssRNA and the replication intermediate dsRNA into the cytosol. Silvio Antoniak, and Nigel Mackman Blood 2014;123: ©2014 by American Society of Hematology