Glioma-derived soluble factor(s) enhance IL-10 signaling.

Slides:

Advertisements

Similar presentations

The expression and signaling of FGFR3 in WM cells.

Advertisements

AF647-RIS is internalized by TAMs in vivo.

IL-1β stimulates CXCL5 and CXCL8 gene expression and protein secretion in A549 cells in a time- and dose-dependent manner. IL-1β stimulates CXCL5 and CXCL8.

Glycoprotein Nonmelanoma Clone B Regulates the Crosstalk between Macrophages and Mesenchymal Stem Cells toward Wound Repair Bing Yu, Talib Alboslemy,

Retinoic acid inhibits Th17 polarization and enhances FoxP3 expression through a Stat-3/Stat-5 independent signaling pathway by Kevin M. Elias, Arian Laurence,

Lineages of human T-cell clones, including T helper 17/T helper 1 cells, isolated at different stages of anti–factor VIII immune responses by Ruth A. Ettinger,

Prostaglandin E2 is a key factor for CCR7 surface expression and migration of monocyte-derived dendritic cells by Elke Scandella, Ying Men, Silke Gillessen,

LEF-1 is a prosurvival factor in chronic lymphocytic leukemia and is expressed in the preleukemic state of monoclonal B-cell lymphocytosis by Albert Gutierrez,

Sunitinib plus rMVA–CEA–TRICOM vaccine decreased tumor burden and increased intratumoral infiltration of T lymphocytes in the MC38-CEA colon carcinoma.

TIE2hi/VEGFAhi TEMs are present in the TMEM

Human Keratinocytes Express Functional CD14 and Toll-Like Receptor 4

Soluble PD-1 ligands regulate T-cell function in Waldenstrom macroglobulinemia by Shahrzad Jalali, Tammy Price-Troska, Jonas Paludo, Jose Villasboas, Hyo-Jin.

Human IL-31 is induced by IL-4 and promotes TH2-driven inflammation

IL-6 is dispensable for the suppressive activity of MDSC on primary CD4+ T-cell activation. IL-6 is dispensable for the suppressive activity of MDSC on.

PDGFRα GBM primary cultures demonstrate titratable and temporal DOX-inducible expression of hPDGF-A and receptor activation. PDGFRα GBM primary cultures.

Colocalisation of NLRP3 specks with cleaved interleukin (IL)-1β in bronchoalveolar lavage (BAL) macrophages, and nontypeable Haemophilus influenzae (NTHi)-stimulated.

Increased chemokine content and leukocyte infiltrate in D6-negative tumors. Increased chemokine content and leukocyte infiltrate in D6-negative tumors.

CHK1 downregulation upon ERG overexpression.

Volume 42, Issue 5, Pages (May 2015)

Volume 141, Issue 5, Pages e2 (November 2011)

Katherine G. MacDonald, BSc, Nicholas A. J

Microarray analysis of phospho-Twist1–responsive genes.

HIF-1α is critically involved in hypoxia-induced CD137 upregulation.

Response of monocytes to hY4 delivery and cytokine levels in CLL serum

IL-27 Suppresses Antimicrobial Activity in Human Leprosy

Role of IL-27 in expression of PD-L1, LAG-3, and CTLA-4 depends on strength of α-CD3/28 signaling. Role of IL-27 in expression of PD-L1, LAG-3, and CTLA-4.

Volume 13, Issue 12, Pages (December 2015)

Myeloma cell–derived Runx2 promotes myeloma progression in bone

Stephen E. Gould, Maria Day, Simon S. Jones, Haimanti Dorai

Baricitinib treatment in a patient with a gain-of-function mutation in signal transducer and activator of transcription 1 (STAT1) Kornvalee Meesilpavikkai,

TLR9 deficiency promotes aberrant T cell and myeloid dendritic cell (DC) phenotype in imiquimod-induced autoimmunity. TLR9 deficiency promotes aberrant.

Isabelle Plaisance et al. BTS 2016;j.jacbts

Defective negative regulation of Toll-like receptor signaling leads to excessive TNF-α in myeloproliferative neoplasm by Hew Yeng Lai, Stefan A. Brooks,

Epithelial loss of TβRII results in increased Th17 cell development.

2aG4 directly induces monocytic MDSCs to differentiate into dendritic cells and macrophages by binding to phosphatidylserine on their cell surface. 2aG4.

Volume 44, Issue 4, Pages (April 2016)

Figure 2 P2Y12 expression is upregulated in M2-polarized human microglia(A, B) Using TaqMan quantitative real-time PCR, P2Y12 expression was measured in.

Expression changes of specific epigenetic-controlled tumor-related genes by the prenatal/maternal BSp treatment. qRT-PCR and Western blot analysis were.

IFN-γ and TNF-α cause an upregulation of Fas expression in human ESCs

SIRT1 is downregulated in human gastric cancer (GC).

ONC201 activates the ISR. ONC201 activates the ISR. (A) Western blotting analysis for ATF4, CHOP, ATF3, and TRB3 on lysates from HCT116 cells cultured.

Senescence-associated defective HLA-DR upregulation does not modulate immunosuppressive properties of MSCs. (A) Fit and senescent MSCs were subjected to.

Regulation of IL-13 receptor α1 expression and signaling on human tonsillar B- lymphocyte subsets Oumnia Hajoui, PhD, Huaien Zheng, MD, PhD, Julie Guay,

Exosome-mediated inhibition of T cells is reversible.

Fig. 1. DEL-1 is expressed by human and mouse osteoclasts.

Ribosomal RNA and β-catenin mRNA localize to newly formed presynaptic terminals. Ribosomal RNA and β-catenin mRNA localize to newly formed presynaptic.

Increased CCL5 expression, infiltration of Treg cells, and apoptosis of CD8+ T cells in human colorectal tissues. Increased CCL5 expression, infiltration.

Reduced tumor growth in CCR5-deficient mice is associated with perturbed killing ability of Treg cells. Reduced tumor growth in CCR5-deficient mice is.

CD49b+ cells from tumor-bearing mice are more prone to conversion into MDSCs compared with naive CD49b+ cells. CD49b+ cells from tumor-bearing mice are.

A, GP and GR epithelial tumor cells are equally responsive to gefitinib. A, GP and GR epithelial tumor cells are equally responsive to gefitinib. Equal.

Spn promotes Rac1 GTPase activation in glioblastoma (GBM) cells.

Volume 10, Issue 7, Pages (February 2015)

Induction of cytotoxic activity in humanized SCC3 tumor-bearing mice treated with anti-PD-1 antibody. Induction of cytotoxic activity in humanized SCC3.

Expression pattern of TLR-4 and MyD88 in EOC cells.

CDN–treated MOC1 tumors demonstrate enhanced activation of innate and antigen-specific adaptive immunity. CDN–treated MOC1 tumors demonstrate enhanced.

ALT-803 stimulates proliferation and activation of human NK cells and T cells in vitro. ALT-803 stimulates proliferation and activation of human NK cells.

Secretion of TNF-α from macrophages and monocytic cells were reduced by the deletion of Nrdc. Secretion of TNF-α from macrophages and monocytic cells were.

PAP- and PA2024-specific CTLs at week 0 (prior to sipuleucel-T infusion) and at weeks 6 and 26 post–sipuleucel-T treatment. PAP- and PA2024-specific CTLs.

CA-MSCs differentially secrete GM-CSF.

Reduced klotho expression in pancreatic cancer.

The channel-kinase TRPM7 regulates antigen gathering and internalization in B cells by Mithunah Krishnamoorthy, Laabiah Wasim, Fathima Hifza Mohamed Buhari,

PDGFAA is a major component of the bioactive fractions generated from Calu-6 conditioned medium. PDGFAA is a major component of the bioactive fractions.

Expression of HO-1 by the FAP+/F4/80+ tumoral macrophages.

Anti-CD40 activates TAMs and recruits inflammatory monocytes.

CpG oligodeoxynucleotide (CpG ODN)–induced activation of different types of primary malignant B cells. CpG oligodeoxynucleotide (CpG ODN)–induced activation.

Hcy decreases VEGFR1/2 and Angs (Ang1, Ang2) gene transcription

Expression of chemokine receptors in A-498 cell line.

Increased tumorigenic activities of TIM-3–expressing RCC cells.

CD36 expression in tissue adjacent and distal to the tumor.

Treatment with octyl-D-2-HG and octyl-L-2-HG reduces MIR148A expression. Treatment with octyl-D-2-HG and octyl-L-2-HG reduces MIR148A expression. A, Treatment.

Presentation transcript:

Glioma-derived soluble factor(s) enhance IL-10 signaling. Glioma-derived soluble factor(s) enhance IL-10 signaling. A, human IL-10 expression measured by ELISA from culture media of normal monocytes stimulated with glioma-conditioned media before and after 24 hours of culture. None of the conditioned media initially contained appreciable levels of IL-10. After 24 hours, IL-10 expression was significantly increased in cells stimulated with glioma-conditioned media compared with normal media (*, P < 0.01). Columns represent mean total IL-10 ± SEM from 3 independent samples. B, IL-10 receptor expression was measured by flow cytometry in monocytes stimulated with glioma-conditioned media. Compared with unstimulated cells, treated monocytes had a modest but significant increase in IL-10R mean fluorescence intensity (*, P < 0.05; **, P < 0.01). Columns represent mean fluorescence intensity ± SEM from 3 independent samples. Each sample was tested in triplicate and averaged as a single data point. C, time course of IL-10 and B7-H1 mRNA expression in normal monocytes stimulated with SF1U-conditioned media. Transcript levels were measured at 0, 1, 6, 12, and 24 hours after stimulation using quantitative RT-PCR and normalized to 18S rRNA. Normalized expression is reported as a relative increase over initial expression. Each point represents mean relative expression ± SEM from 3 independent samples. D, representative section of GBM tissue with fluorescent immunestaining for CD163 (red), B7-H1 (green), IL-10 (cyan), and 4′, 6–diamidino–2–phenylindole (DAPI; blue) showing colocalization of all 3 probes to the same subset of tumor-associated macrophages (scale bar = 10 μm). Orin Bloch et al. Clin Cancer Res 2013;19:3165-3175 ©2013 by American Association for Cancer Research