Three ‐ dimensional solution structure of the 44 kDa ectodomain of SIV gp41 by Michael Caffrey, Mengli Cai, Joshua Kaufman, Stephen J. Stahl, Paul T. Wingfield,

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Three ‐ dimensional solution structure of the 44 kDa ectodomain of SIV gp41 by Michael Caffrey, Mengli Cai, Joshua Kaufman, Stephen J. Stahl, Paul T. Wingfield, David G. Covell, Angela M. Gronenborn, and G.Marius Clore EMBO J. Volume 17(16): August 17, 1998 ©1998 by European Molecular Biology Organization

Secondary structure of SIV e ‐ gp41, and alignment of SIV (Sooty Mangabey) and HIV ‐ 1 (consensus sequence; Douglas et al., 1997) e ‐ gp41. Michael Caffrey et al. EMBO J. 1998;17: ©1998 by European Molecular Biology Organization

(A) A 1H ‐ 13C plane taken from a 4D 13C/13C ‐ edited NOE spectrum (80 ms mixing time) recorded on 13C/15N ‐ labeled SIV e ‐ gp41. Michael Caffrey et al. EMBO J. 1998;17: ©1998 by European Molecular Biology Organization

Stereoviews showing best ‐ fit superpositions of (a) the backbone (N, Cα, C′) and (b) selected side chains of the ensemble of 40 simulated annealing structures of SIV e ‐ gp41. Michael Caffrey et al. EMBO J. 1998;17: ©1998 by European Molecular Biology Organization

Ribbon diagrams of SIV e ‐ gp41 viewed from (a) the top (upper panel) and bottom (lower panel) and (b) the side with respect to the viral membrane (note that the transmembrane segment of gp41 is connected to the C ‐ terminal helices via a flexible 20 residue li... Michael Caffrey et al. EMBO J. 1998;17: ©1998 by European Molecular Biology Organization

(a) Overall view of SIV e ‐ gp41 illustrating the distribution of amino acid types with the backbone shown as a Cα worm (white), and hydrophobic (aliphatic and aromatic), positively charged (Arg, Lys and His), negatively charged (Asp and Glu) and other amino... Michael Caffrey et al. EMBO J. 1998;17: ©1998 by European Molecular Biology Organization

Mapping of (a) the electrostatic potential and (b) the two highest ranking surface hydrophobic clusters on the molecular surface of SIV e ‐ gp41. Michael Caffrey et al. EMBO J. 1998;17: ©1998 by European Molecular Biology Organization

Comparison of the solution structure of SIV e ‐ gp41 with the X ‐ ray structures of truncated versions of HIV ‐ 1 e ‐ gp41. Michael Caffrey et al. EMBO J. 1998;17: ©1998 by European Molecular Biology Organization

Comparison of the structure of SIV e ‐ gp41 with the neutral (Wilson et al., 1981; Weis et al., 1990) and low (Bullough et al., 1994) pH forms of HA2. Michael Caffrey et al. EMBO J. 1998;17: ©1998 by European Molecular Biology Organization

Model for (A) the inhibitory effects of peptides derived from the N ‐ and C ‐ terminal helices and (B) gp41 ‐ mediated fusion. Michael Caffrey et al. EMBO J. 1998;17: ©1998 by European Molecular Biology Organization