GAP G6P Ru5P CO 2 F6P 6PG OAA CIT ICIT AKG SUC PEP PYR AcCoA 3PG S7P GLOX X5P R5P E4P F6P FUM Glucose ①②③④⑤⑥ ( ④⑤⑥ ) ( ③②① ④⑤⑥ ) (①)(①) ( ②③④⑤⑥ ) RuBP.

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GAP G6P Ru5P CO 2 F6P 6PG OAA CIT ICIT AKG SUC PEP PYR AcCoA 3PG S7P GLOX X5P R5P E4P F6P FUM Glucose ①②③④⑤⑥ ( ④⑤⑥ ) ( ③②① ④⑤⑥ ) (①)(①) ( ②③④⑤⑥ ) RuBP GAP ( ①②①②③④⑤ ) ( ①②③ ) CO 2 ① ( ①②① ③④⑤ ) ( ①②①②③④ ) 3PG Glct ( ②① ) ① ( ①②③① ) ( ④③②②①① ) MAL ( ②③ ) GLX SER CO 2 GLY C1 CO 2 GLY PHE TYR ①②③④⑤⑥ ①②③④⑤ ①② ①②③ ( ③④⑤ ) ( ①②③④⑤⑥ ) ( ①②③④⑤ ) ( ①② ) ①② ( ①② ) ①②③④⑤⑥ ( ①②③④⑤⑥ ) ①②③ ( ①②③ ) ①②③ ( ①②③ ) ①②③ ①② ①②③④ ①②③④⑤⑥ ( ①②③④⑤⑥ ) ①②③④⑤⑥ ( ①②③④⑤ ) ①②③④⑤ ( ⑤④③② ) ①②③④ ( ②③④⑤ ) ①②③④ ( ①②③④ ) ( ④③②① ) ( ①②③④ ) ( ④③②① ) ①②③④ ( ①②③ ) CO 2 (④)(④) ① ( ①② ) ①② ( ⑥③④⑤ ⑤④③⑥ ) ( ①②②① ) ( ①②③④⑤ ) ①②③④⑤ ( ③④⑤ ) ①②③④⑤⑥⑦ ①②③ ( ①②③①②③ ) ( ④⑤⑥⑦ ) ①②③④⑤⑥ ①②③④ ( ③④⑤ ) ( ①② ) ①②③ ( ①②③ ) ①② (③)(③) (①)(①) (②)(②) ① ( ①②③ ) ① CO 2 (①)(①) ① (⑥)(⑥) ① ① (①)(①) methysuccinyl-CoA ① ( ①①②①② ) CO 2 ①②③④⑤ ( ① and ④ ) propionyl-CoA ( ④③ ) GLOX ①②③ ( ①②⑤ ) CO 2 ① SUC-CoA ①②③④ ( ①②③① ) ( ①②③④ or ④③②① ) malonyl-CoA 3-hydroxypropionate ( ①②① ) ①②③ ( ①②③ ) ①②③ malyl-CoA ( ①②③④ ) ( ①② ) ①②③④ AcCoA ①② ( ④③ ) SER C1 ①②③ ( ①②③ ) (③)(③) ( ①② ) 4-hydroxybutyrate ( ④③②① ) Acetoacetyl-CoA ( ①②③④ ) ①②③④ AcCoA ①② ( ①② ) ( ③④ ) ALA PYR ①②③ Citramalate ( ①②②①③ ) ①②③④⑤ CO 2 ① ( ④③②⑤ ) 2-ketobutyrate ①②③④ 2-hydroxyethyl-ThPP ( ②③ ) ①② ( ①②③①②④ ) 2-keto-3-methyl-valerate ①②③④⑤⑥ Ile ( ①②②③④① ) CO (①)(①) formate (②)(②) CO 2 ① ① ① ① CYS ① ( ③②① ) (①)(①) CO 2 ① (①)(①) (①①)(①①)

GlycolysisOxidative Pentose Phosphate Pathway Glucose (abcdef)  G6P (abcdef)G6P (abcdef)  6PG (abcdef) G6P (abcdef)  F6P (abcdef)6PG (abcdef)  Ru5P (bcdef) + CO 2 (a) F6P (abcdef)  FBP (abcdef)Ru5P (abcde)  X5P (abcde) FBP (abcdef)  DHAP (cba) + GAP (def)Ru5P (abcde)  R5P (abcde) DHAP (abc)  GAP (abc)X5P (abcde) + R5P (fghij)  S7P (abfghij) + GAP (cde) GAP (abc)  3PG (abc)S7P (abcdefg) + GAP (hij)  F6P (abchij) + E4P (defg) 3PG (abc)  PEP (abc)X5P (abcde) + E4P (fghi)  F6P (abfghi) + GAP (cde) PEP (abc)  PYR (abc) Calvin Cycle TCA Cycle Ru5P (abcde)  RuBP (abcde) PYR (abc)  AcCoA (bc) + CO 2 (a)RuBP (abcde) + CO 2 (f)  3PG (fba + cde) OAA (abcd) + AcCoA (ef)  CIT (dcbfea)X5P (abcde)  Ru5P (abcde) OAA (abcd) + AcCoA (ef)  CIT (efbcda) Citrate (Re)-synthaseR5P (abcde)  Ru5P (abcde) CIT(abcdef)  ICIT (abcdef)GAP (abc) + S7P (defghjk)  X5P (deabc) + R5P (fghjk) ICIT (abcdef)  AKG (abcde) + CO 2 (f)E4P (abcd) + F6P (efghjk)  GAP (hjk) + S7P (efgabcd) AKG (abcde)  SucCoA (½ bcde + ½ edcb) + CO 2 (a)GAP (abc) + F6P (defghi)  X5P (deabc) + E4P (fghi) SucCoA (abcd)  SUC (½ abcd + ½ dcba)E4P (abcd) + DHAP (efg)  SBP (gfeabcd) SUC (½ abcd + ½ dcba)  FUM (½ abcd + ½ dcba)SBP (abcdefg)  S7P(abcdefg) FUM (½ abcd + ½ dcba)  MAL (abcd) C1 metabolism MAL (abcd)  OAA (abcd)Ser (abc)  GLY (ab) + C1 (c ) EMCP Pathway GLY (ab)  C1 (b) + CO 2 (a) AcCoA (ab) + AccoA (cd) + CO 2 (e)  methylsuccinyl-CoA (acdeb) Amino Acid Biosynthesis methylsuccinyl-CoA (abcde)  propionyl-CoA (abe) +GLOX (dc) AKG (abcde)  Glu (abcde) propionyl-CoA (abc) + CO 2 (d)  SucCoA (abcd) Glu (abcde)  Gln (abcde) 3-hydroxypropionate/4-hydroxybutyrate pathway Glu (abcde)  Pro (abcde) AcCoA (ab) + CO 2 (c)  malonyl-CoA (abc) Glu (abcde) + CO 2 (f)  Arg (abcdef) malony-CoA (abc)  3-hydroxypropionate (cba)OAA (abcd)  Asp (abcd) 3-hydroxypropionate (abc)  propionyl-CoA (abc) Asp (abcd)  Asn (abcd) propionyl-CoA (abc) + CO 2 (d)  SucCoA (abcd) PYR (abc)  Ala (abc) SucCoA (abcd) + malate (efgh)  SUC (abcd) + malyl-CoA (efgh) 3PG (abc)  Ser (abc) malyl-CoA (abcd)  GLOX (dc) + AcCoA (ab) Thr (abcd)  Gly (ab) + AcCoA (cd) + NADH SucCoA (abcd)  4-hydroxybutyrate (dcba) Ser (abc)  Cys (abc) 4-hydroxybutyrate (abcd)  AcCoA (ab + cd)Asp (abcd) + PYR (efg)  LYS (1/2 bcdgfe + 1/2 fgdcba) Entner-Doudoroff Pathway Asp (abcd)  Thr (abcd) 6PG (abcdef)  PYR (abc) + GAP (def)Asp (abcd) + C1 (e)  Met (abcde) Glyoxylate Shunt Pyr (abc) + Pyr (def)  Val (abcef) + CO 2 (d) ICIT (abcdef)  GLOX (ab) + SUC (½ edcf + ½ fcde)AcCoA (ab) + Pyr (cde) + Pyr (fgh)  Leu (abdghe) + CO 2 (c + f) GLOX (ab) + AcCoA (cd)  MAL (abdc)Thr (abcd) + Pyr (efg)  Ile (abfcdg) + CO 2 (e) Anaplerotic Reactions PEP (abc) + PEP (def) + E4P (ghij)  Phe (abcefghij) + CO 2 (d) MAL (abcd)  PYR (abc) + CO 2 (d) PEP (abc) + PEP (def) + E4P (ghij)  Tyr (abcefghij) + CO 2 (d) MAL (abcd)  PYR (abc) + CO 2 (d) Ser (abc) + R5P (defgh) + PEP (ijk) + E4P (lmno)  Trp (abcedklmnoj) + CO 2 (i) + GAP (fgh) PEP (abc) + CO 2 (d)  OAA (abcd) R5P (abcde) + C1 (f)  His (edcbaf) OAA (abcd)  PEP (abc) + CO 2 (d) Citramalte pathway Wood-Ljungdahl pathway AcCoA (ab) + PYR (cde)  Citramalate (cdbae) AcCoA (ab)  CO (a) + formate (b) Citramalate (abcde)  2-ketobutyrate (dcbe) + CO 2 (a) formate (a)  CO 2 (a) 2-ketobutyrate (abcd) + PYR (efg)  Ile (abcfgd) + CO 2 (e)