Critical role for Syk in responses to vascular injury by Patrick Andre, Toshifumi Morooka, Derek Sim, Keith Abe, Clifford Lowell, Nisha Nanda, Suzanne.

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Presentation transcript:

Critical role for Syk in responses to vascular injury by Patrick Andre, Toshifumi Morooka, Derek Sim, Keith Abe, Clifford Lowell, Nisha Nanda, Suzanne Delaney, Gail Siu, Yibing Yan, Stan Hollenbach, Anjali Pandey, Huiyun Gao, Yunmei Wang, Kohsuke Nakajima, Sahil A. Parikh, Can Shi, David Phillips, Whyte Owen, Uma Sinha, and Daniel I. Simon Blood Volume 118(18): November 3, 2011 ©2011 by American Society of Hematology

Lack of Syk attenuates arterial thrombus formation ex vivo. Patrick Andre et al. Blood 2011;118: ©2011 by American Society of Hematology

Kinase specificity of PRT and activity on human platelet function. Patrick Andre et al. Blood 2011;118: ©2011 by American Society of Hematology

Syk inhibition affects both thrombus initiation and thrombus stability in human blood. Patrick Andre et al. Blood 2011;118: ©2011 by American Society of Hematology

PRT inhibits arterial and venous thrombosis in the mouse. Patrick Andre et al. Blood 2011;118: ©2011 by American Society of Hematology

PRT inhibits neointima formation after femoral artery wire injury. Patrick Andre et al. Blood 2011;118: ©2011 by American Society of Hematology

Atherosclerotic lesion formation is attenuated by PRT Patrick Andre et al. Blood 2011;118: ©2011 by American Society of Hematology

PRT activity in rabbits and pigs. Patrick Andre et al. Blood 2011;118: ©2011 by American Society of Hematology