Role of Store-Operated Calcium Channels and Calcium Sensitization in Normoxic Contraction of the Ductus Arteriosus by Zhigang Hong, Fangxiao Hong, Andrea.

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Presentation transcript:

Role of Store-Operated Calcium Channels and Calcium Sensitization in Normoxic Contraction of the Ductus Arteriosus by Zhigang Hong, Fangxiao Hong, Andrea Olschewski, Jesus A. Cabrera, Anthony Varghese, Daniel P. Nelson, and E. Kenneth Weir Circulation Volume 114(13): September 26, 2006 Copyright © American Heart Association, Inc. All rights reserved.

Figure 1. A, Representative tension tracing showing the effect of 1 μmol/L nifedipine (NIF) on normoxia-induced DA ring contraction. Zhigang Hong et al. Circulation. 2006;114: Copyright © American Heart Association, Inc. All rights reserved.

Figure 2. A, Representative DA ring tension trace showing that in the presence of TG (100 nmol/L, to empty intracellular calcium stores) and nifedipine (NIF; 1 μmol/L, to block L-type calcium channels), normoxia causes only a small contraction in DA rings when the bath solution contains no calcium. Zhigang Hong et al. Circulation. 2006;114: Copyright © American Heart Association, Inc. All rights reserved.

Figure 3. A, Fura2 measurement of calcium in DASMCs showing that normoxia causes an increase in cytosolic Ca2+ in the presence of the L-type Ca2+ channel blocker nifedipine (NIF). Zhigang Hong et al. Circulation. 2006;114: Copyright © American Heart Association, Inc. All rights reserved.

Figure 4. A, TRPC1, TRPC3, TRPC4, and TRPC6 mRNA are identified by reverse transcription polymerase chain reaction in fetal rabbit DA. Both rabbit (oTPRC1) and mouse (mTRPC1) primer proteins are used to detect TRPC1. β-Actin is used as a positive control. Zhigang Hong et al. Circulation. 2006;114: Copyright © American Heart Association, Inc. All rights reserved.

Figure 5. SOCs in single DASMCs. A, In freshly isolated resistance DASMCs, 30 μmol/L CPA activates inward current at negative potentials (−80 mV) (n=4 for similar recordings). Zhigang Hong et al. Circulation. 2006;114: Copyright © American Heart Association, Inc. All rights reserved.

Figure 6. A, Representative DA ring tension tracing shows the experimental protocol and illustrates that 3 μmol/L Y completely reverses (posttreated, top) or prevents (pretreated, bottom) normoxia-induced contraction. Zhigang Hong et al. Circulation. 2006;114: Copyright © American Heart Association, Inc. All rights reserved.