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Hypothermia for Neonatal Hypoxic Ischemic Encephalopathy: An Updated Systematic Review and Meta-analysis Tagin MA, Woolcott CG, Vincer MJ, Whyte RK, Stinson.

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Copyright © 2016 American Medical Association. All rights reserved. From: Hypothermia for Neonatal Hypoxic Ischemic Encephalopathy: An Updated Systematic Review and Meta-analysis Arch Pediatr Adolesc Med. 2012;166(6):558-566. doi:10.1001/archpediatrics.2011.1772 Figure Legend: Figure 1. Publication bias funnel plots for the primary outcome. A, Publication bias funnel plot for death or severe disability in newborns with moderate hypoxic ischemic encephalopathy. B, Publication bias funnel plot for death or severe disability in newborns with severe hypoxic ischemic encephalopathy. Date of download: 9/18/2016 Copyright © 2016 American Medical Association. All rights reserved.

Copyright © 2016 American Medical Association. All rights reserved. From: Hypothermia for Neonatal Hypoxic Ischemic Encephalopathy: An Updated Systematic Review and Meta-analysis Arch Pediatr Adolesc Med. 2012;166(6):558-566. doi:10.1001/archpediatrics.2011.1772 Figure Legend: Figure 2. Forest plot of the composite primary outcome of death or major disability in survivors. Diamond indicates overall summary estimate for the analysis (width of the diamond represents the 95% CI). M-H indicates Mantel-Haenzel test. Date of download: 9/18/2016 Copyright © 2016 American Medical Association. All rights reserved.

Copyright © 2016 American Medical Association. All rights reserved. From: Hypothermia for Neonatal Hypoxic Ischemic Encephalopathy: An Updated Systematic Review and Meta-analysis Arch Pediatr Adolesc Med. 2012;166(6):558-566. doi:10.1001/archpediatrics.2011.1772 Figure Legend: Figure 3. Forest plot of components of the composite primary outcome. Blindness and deafness were not reported in the study by Zhou et al. M-H indicates Mantel-Haenzel test. Date of download: 9/18/2016 Copyright © 2016 American Medical Association. All rights reserved.

Copyright © 2016 American Medical Association. All rights reserved. From: Hypothermia for Neonatal Hypoxic Ischemic Encephalopathy: An Updated Systematic Review and Meta-analysis Arch Pediatr Adolesc Med. 2012;166(6):558-566. doi:10.1001/archpediatrics.2011.1772 Figure Legend: Figure 4. Forest plot of survival with normal neurological function (“events”). Diamond indicates overall summary estimate for the analysis (width of the diamond represents the 95% CI). M-H indicates Mantel-Haenzel test. Date of download: 9/18/2016 Copyright © 2016 American Medical Association. All rights reserved.

Copyright © 2016 American Medical Association. All rights reserved. From: Hypothermia for Neonatal Hypoxic Ischemic Encephalopathy: An Updated Systematic Review and Meta-analysis Arch Pediatr Adolesc Med. 2012;166(6):558-566. doi:10.1001/archpediatrics.2011.1772 Figure Legend: Figure 5. Forest plot of the primary outcome of death or major disability in survivors in newborns with moderate to severe hypoxic ischemic encephalopathy. Diamond indicates overall summary estimate for the analysis (width of the diamond represents the 95% CI). M-H indicates Mantel-Haenzel test. Date of download: 9/18/2016 Copyright © 2016 American Medical Association. All rights reserved.

Copyright © 2016 American Medical Association. All rights reserved. From: Hypothermia for Neonatal Hypoxic Ischemic Encephalopathy: An Updated Systematic Review and Meta-analysis Arch Pediatr Adolesc Med. 2012;166(6):558-566. doi:10.1001/archpediatrics.2011.1772 Figure Legend: Figure 6. Forest plot for the primary outcome of death or major disability by method of cooling in newborns with moderate to severe encephalopathy. Diamond indicates overall summary estimate for the analysis (width of the diamond represents the 95% CI). M-H indicates Mantel-Haenzel test. Date of download: 9/18/2016 Copyright © 2016 American Medical Association. All rights reserved.