Date of download: 9/18/2016 Copyright © ASME. All rights reserved. From: Computational Modeling of the Mechanical Behavior of the Cerebrospinal Fluid System J Biomech Eng. 2004;127(2): doi: / Schematic median sagittal cut of the human brain displaying CSF circulation. Arrows indicate flow direction. L: lateral ventricles, Mo: foramen of Monro, III: third ventricle, Aq: aqueduct of Sylvius, IV: fourth ventricle, A: arachnoid villi, C: cerebellomedullary cistern, ChP: choroid plexus of lateral ventricles, S: superior sagittal sinus. (Based on: Putz/Pabst: Sobotta, Atlas der Anatomie des Menschen, 21th ed. 2000, © Elsevier, Urban & Fischer München. Used with permission). Figure Legend:

Date of download: 9/18/2016 Copyright © ASME. All rights reserved. From: Computational Modeling of the Mechanical Behavior of the Cerebrospinal Fluid System J Biomech Eng. 2004;127(2): doi: / Schematic of a general single compartment model Figure Legend:

Date of download: 9/18/2016 Copyright © ASME. All rights reserved. From: Computational Modeling of the Mechanical Behavior of the Cerebrospinal Fluid System J Biomech Eng. 2004;127(2): doi: / Rendering of a ventricular system segmented from in vivo MRI data. Data provided by Dr. P. Summers, Institute of Neuroradiology, University Hospital Zurich. Figure Legend:

Date of download: 9/18/2016 Copyright © ASME. All rights reserved. From: Computational Modeling of the Mechanical Behavior of the Cerebrospinal Fluid System J Biomech Eng. 2004;127(2): doi: / Aqueduct of Sylvius, center section. Left: normal aqueduct. Right: stenosed aqueduct with a 25% smaller cross-sectional area half way between the third and fourth ventricle. Figure Legend:

Date of download: 9/18/2016 Copyright © ASME. All rights reserved. From: Computational Modeling of the Mechanical Behavior of the Cerebrospinal Fluid System J Biomech Eng. 2004;127(2): doi: / Pressure variation in the lateral ventricles in dependence of the third ventricle displacement and velocity. The graphs apply to both the ventricular system with and without aqueduct stenosis. Figure Legend:

Date of download: 9/18/2016 Copyright © ASME. All rights reserved. From: Computational Modeling of the Mechanical Behavior of the Cerebrospinal Fluid System J Biomech Eng. 2004;127(2): doi: / Average pressure in the lateral ventricles over the course of one cycle, both in cases with and without aqueduct stenosis. Figure Legend:

Date of download: 9/18/2016 Copyright © ASME. All rights reserved. From: Computational Modeling of the Mechanical Behavior of the Cerebrospinal Fluid System J Biomech Eng. 2004;127(2): doi: / Maximum axial velocity in the aqueduct of Sylvius midway between the third and fourth ventricle. One cycle for both the stenosed and the regular system is depicted. Figure Legend: