function Enrichment Score Enrichment p- value % genes in group that are present # genes in list, in group positive regulation of fever generation E positive regulation of nitric oxide biosynthetic process E peroxidase activity E haptoglobin-hemoglobin complex E sequestering of triglyceride E positive regulation of calcidiol 1-monooxygenase activity E negative regulation of cell proliferation E humoral immune response immune response oxygen transport regulation of I-kappaB kinase/NF-kappaB cascade inflammatory response ovulation positive regulation of chemokine biosynthetic process chemokine activity positive regulation of membrane protein ectodomain proteolysis oxygen transporter activity hemoglobin complex negative regulation of lipid catabolic process positive regulation of cell death positive regulation vascular endothelial growth factor production embryonic digestive tract development positive regulation of NF-kappaB import into nucleus hydrogen peroxide catabolic process response to vitamin D response to glucocorticoid stimulus neutrophil chemotaxis positive regulation of interferon-gamma production positive regulation of mitosis cellular component movement positive regulation of interleukin-6 production cell cycle arrest response to organic nitrogen calcium-mediated signaling embryo implantation memory heme binding chemotaxis external side of plasma membrane oxygen binding positive regulation of JNK cascade response to organic cyclic compound protein heterooligomerization positive regulation of smooth muscle cell proliferation response to hydrogen peroxide extracellular space extracellular matrix organization positive regulation of ERK1 and ERK2 cascade regulation of blood pressure positive regulation of sequence-specific DNA binding transcription factor activity extracellular region Table S6. GO categories down-regulated in late acute phase vs convalscent phase(p <0.05) (HG-focus platform)

Figure S6 Continued anti-apoptosis positive regulation of protein phosphorylation regulation of insulin secretion positive regulation of NF-kappaB transcription factor activity activation of MAPK activity response to estradiol stimulus apoptosis leukocyte migration positive regulation of I-kappaB kinase/NF-kappaB cascade sugar binding signal transduction response to lipopolysaccharide response to drug angiogenesis cytokine activity