Hepatitis Viral Hepatitis is a group of disease that infect the liver. Three viruses - Hepatitis A, Hepatitis B and Hepatitis C are the most frequent viruses.

Hepatitis A Hepatitis A is a frequent virus of childhood and is not considered a deadly and serious infection. It is most commonly transmitted via the fecal-oral route through contaminated food or drinking water.

Hepatitis B Hepatitis B is an infectious viral disease transmitted by body fluids or needles (including unprotected sex) Hepatitis B can cause severe acute infections and severe chronic infections.

Hepatitis C (HCV) Hepatitis C is transmitted through blood routes, needles, tattoos and sexual activity. Hepatitis C is a quiet virus that may not be noticed This virus may slowly eat away at your liver causing scarring and damage and finally almost total liver destruction. Link

Prevelance of HCV

Treatment of HCV Current treatment is a combination off pegylated interferon alpha (Pagasys and PEG-Intron) combined with the antiviral drug ribavirin for a period of 24 to 48 weeks.

Interferon alpha Interferons are proteins produced by the immune system in response to viruses Interferons serve to activate the immune system, specifically MHC 1 (major histocompatibility complex 1), thus giving a signal to T cells. Link

Pegylated Interferon alfa-2a This protein derivative is formed by the addition of polyethylene glycol (structure above) to the interferon, leading to an enhanced lifetime of the interferon

Ribavirin Ribavirin resembles both adenosine and guanosine and may become incorporated into growing strands of RNA However the carboxamide group pairs equally well with both uracil or cytosine, thus leading to mutations in RNA-dependent RNA polymerases. Ribavirin also acts as an inhibitor of inosine 5’-monophosphate dehydrogenase, a crucial enzyme in the biosynthesis of RNA.