Casein kinase I epsilon interacts with mitochondrial proteins for the growth and survival of human ovarian cancer cells by Noah Rodriguez, Junzheng Yang,

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Casein kinase I epsilon interacts with mitochondrial proteins for the growth and survival of human ovarian cancer cells by Noah Rodriguez, Junzheng Yang, Kathleen Hasselblatt, Shubai Liu, Yilan Zhou, Jose A. Rauh ‐ Hain, Shu ‐ Kay Ng, Pui ‐ Wah Choi, Wing ‐ Ping Fong, Nathalie Y. R. Agar, William R. Welch, Ross S. Berkowitz, and Shu ‐ Wing Ng EMBO Mol Med. Volume 4(9): September 4, 2012 ©2012 by European Molecular Biology Organization

Expression of CKIε in ovarian tumours and cancer cell lines.A.Representative figures of immunohistochemical staining of normal ovaries and ovarian tumour tissues for CKIε using the monoclonal mouse anti ‐ human CKIε antibody from BD Biosciences.B.Statistical... Noah Rodriguez et al. EMBO Mol Med. 2012;4: ©2012 by European Molecular Biology Organization

Ectopic expression of CKIε in HOSE cells promotes cell growth and increases spheroid size in Matrigel cultures.A.Western blot analysis using the monoclonal mouse anti ‐ human CKIε from BD Biosciences to show the increased expression of CKIε in the ectopic exp... Noah Rodriguez et al. EMBO Mol Med. 2012;4: ©2012 by European Molecular Biology Organization

Inhibition of CKIε in ovarian cancer cells suppressed cell proliferation, migration rate and in vivo tumour burden.A.MTT assays to investigate the effects of CKIε/δ inhibitors IC261, PF ‐ and PF ‐ on the proliferation rate of ovarian cancer cell... Noah Rodriguez et al. EMBO Mol Med. 2012;4: ©2012 by European Molecular Biology Organization

Ovarian cancer cell lines with CKIε knockdown did not show changes in β ‐ catenin activity but reduced expression of mitochondrial protein ANT2.A.Reporter luciferase assay to evaluate any changes in the β ‐ catenin activity of the MCAS ovarian cancer cells harb... Noah Rodriguez et al. EMBO Mol Med. 2012;4: ©2012 by European Molecular Biology Organization

Expression of CKIε in ovarian cancer cells is associated with in vitro chemoresponse and poor clinical outcome of ovarian cancer patients.A.The response of control and CKIε knockdown SKOV3 cells to Taxol and carboplatin as measured by MTT assays.B.Kaplan–Me... Noah Rodriguez et al. EMBO Mol Med. 2012;4: ©2012 by European Molecular Biology Organization