Date of download: 9/18/2016 From: Cost-Effectiveness of Distributing Naloxone to Heroin Users for Lay Overdose Reversal Ann Intern Med. 2013;158(1):1-9.

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Date of download: 9/18/2016 From: Cost-Effectiveness of Distributing Naloxone to Heroin Users for Lay Overdose Reversal Ann Intern Med. 2013;158(1):1-9. doi: / Markov model of heroin use, overdose, discontinuation, and death. Shapes and lines represent health states and transitions, respectively. At each overdose “tunnel state,” which individuals pass through in a set sequence akin to passing through a tunnel, a decision analytic model generated the probability of survival or death. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

Date of download: 9/18/2016 From: Cost-Effectiveness of Distributing Naloxone to Heroin Users for Lay Overdose Reversal Ann Intern Med. 2013;158(1):1-9. doi: / Decision analytic model of an overdose in the setting of naloxone distribution to heroin users. EMS = emergency medical services. * Modified by the likelihood of naloxone being present at an overdose. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

Date of download: 9/18/2016 From: Cost-Effectiveness of Distributing Naloxone to Heroin Users for Lay Overdose Reversal Ann Intern Med. 2013;158(1):1-9. doi: / Relative (top) and absolute (bottom) reduction in overdose death rate among active heroin users from naloxone distribution for lay overdose reversal. Solid lines represent the results of the deterministic model from baseline parameters; other lines represent the results of the probabilistic analysis, including the mean (dotted line) and 95% CI (dashed lines). Absolute rates were adjusted by the number of active heroin users to represent the effect in a community of heroin users at various stages of drug use. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

Date of download: 9/18/2016 From: Cost-Effectiveness of Distributing Naloxone to Heroin Users for Lay Overdose Reversal Ann Intern Med. 2013;158(1):1-9. doi: / One-way sensitivity analyses of naloxone distribution to heroin users for lay overdose reversal. Analyses of all model parameters based on maximum predicted ranges. EMS = emergency medical services; QALY = quality-adjusted life-year. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

Date of download: 9/18/2016 From: Cost-Effectiveness of Distributing Naloxone to Heroin Users for Lay Overdose Reversal Ann Intern Med. 2013;158(1):1-9. doi: / Cost-effectiveness acceptability curve for naloxone distribution under traditional assumptions and applying national drug-related expenditures to heroin users. The y-axis represents the probability that naloxone distribution is preferred at a given willingness to pay and includes a secondary analysis assuming heroin users are a net cost to society. QALY = quality-adjusted life- year. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

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