Drug eruption (Dermatitis medicamentosa). 一.Definition 二.Etiologic Factors (Etiology) (一) The individual factors (二) Drugs.

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Presentation transcript:

Drug eruption (Dermatitis medicamentosa)

一.Definition 二.Etiologic Factors (Etiology) (一) The individual factors (二) Drugs

1.Antibiotics 2. Antipyretic-analgesic drugs 3. Sedative-hypnotic drugs and Antiepileptic drugs 4.Antigout (allopurinol) 5.Heterologous(Foreign) serum and Vaccine etc. 6. Traditional chinese medicine

三.Pathogenesis: (一) Allergic (二) Nonallergic

四.Clinical Findings: (一) Fixed drug eruption : Antipyretic-analgesic drugs Sulfonamides Barbiturates

(二) Urticarial drug eruption : Heterologous(Foreign) serum 、 Furazolidone 、 Penicillin

(三) Morbilliform drug eruption and Scarlatiniform drug eruption : Penicillin Sulfonamides Antipyretic-analgesic drugs Barbiturates

(四) Eczematous drug eruption : Penicillin Streptomycin Sulfonamides Quinine

(五) Purpuric drug eruption : Antibiotics Barbiturates Diuretics

(六) Erythema multiforme drug eruption : Sulfonamides Antipyretic-analgesic drugs Barbiturates

(七) Drug-induced bullosa epidermolysis : Sulfonamides Antipyretic-analgesic drugs Antibiotics Barbiturates

(八) Drug-induced exfoliative dermatitis : Sulfonamides Barbiturates Antiepileptic drugs Antipyretic-analgesic drugs Antibiotics

(九) Acneiform drug eruption : Glucocorticoid

(十) Photosensitive drug eruption : 1. Phototoxic drug eruption 2. Photoallergic drup eruption

五.Diagnosis and Differential Diagnosis 六.Laboratory examination

七.Treatment 1 、 Antihistamine 、 VitC 、 Prednisone(30~60mg/d) 、 50% GS 20ml + 10%Calcii Gluconas 10ml I.V. Qd 5% GS 250ml + 10%Calcii Gluconas 20ml I.V.gtt. Qd Lot. Calamine 、 0.25 % Cream Prednisone 、 0.1 % Sol. Rivanole

2.5%~10% G.S. 500ml + Hydrocortisone 150mg~200mg I.V.gtt. B.i.d. 5%~10% G.S. 500ml + Dexamethasone 5mg~10mg I.V.gtt. B.i.d.

八.Prophylaxis