ABL1 Methylation Is a Distinct Molecular Event Associated With Clonal Evolution of Chronic Myeloid Leukemia by Fotis A. Asimakopoulos, Pesach J. Shteper,

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ABL1 Methylation Is a Distinct Molecular Event Associated With Clonal Evolution of Chronic Myeloid Leukemia by Fotis A. Asimakopoulos, Pesach J. Shteper, Svetlana Krichevsky, Eitan Fibach, Aaron Polliack, Eliezer Rachmilewitz, Yinon Ben-Neriah, and Dina Ben-Yehuda Blood Volume 94(7): October 1, 1999 ©1999 by American Society of Hematology

The position of the Ia CpG island within theBCR-ABL fusion gene is shown. Fotis A. Asimakopoulos et al. Blood 1999;94: ©1999 by American Society of Hematology

Methylation-specific PCR shows ABL1 methylation patterns in CML cell lines. Fotis A. Asimakopoulos et al. Blood 1999;94: ©1999 by American Society of Hematology

Methylation-specific PCR shows ABL1 methylation patterns in clinical samples from acute- phase CML. NBC, normal donor buffy-coat DNA; SssI-NBC, CpG methylase (SssI methylase)- treated normal donor buffy-coat DNA; EM2, CML cell line EM2. Fotis A. Asimakopoulos et al. Blood 1999;94: ©1999 by American Society of Hematology

ABL1 methylation-specific PCR on individual colonies. Fotis A. Asimakopoulos et al. Blood 1999;94: ©1999 by American Society of Hematology

Methylation topology of the ABL1 promoter region. Fotis A. Asimakopoulos et al. Blood 1999;94: ©1999 by American Society of Hematology

(A) Single-step methylation-specific PCR is shown for theMSH6 locus. Fotis A. Asimakopoulos et al. Blood 1999;94: ©1999 by American Society of Hematology