MedHerance MedHerance – Confidential and Proprietary

Problem Statement Compliance with asthma management plans is low – Patients overuse Albuterol instead of their preventer – Getting the right balance of preventer and Albuterol is difficult Currently, there is no readily available solution that tracks the physiological response to Albuterol use MedHerance – Confidential and Proprietary

Sam has Asthma MedHerance – Confidential and Proprietary

Sam’s Parents Are Worried How will we manage Sam’s asthma, especially now he’s starting school? MedHerance – Confidential and Proprietary

Proposed Solution By detecting changes in Heart Rate associated with Albuterol use, we can quickly inform caregivers and PCPs about poor asthma management MedHerance – Confidential and Proprietary

MedHerance Inhaler Management System + Albuterol MedHerance – Confidential and Proprietary

Sam Uses His Inhaler At School We track how many doses he takes What times of day he uses his inhaler We determine if his use is increasing MedHerance – Confidential and Proprietary

Sample Report: Sam’s Inhaler Use Mon 9/15 6am9am 12pm 3pm 6pm9pm12am3am Tue 9/16 Wed 9/17 Thu 9/18 Fri 9/19 Sat 9/20 Sun 9/21 Warning! MedHerance – Confidential and Proprietary

Initial Market Opportunity: Consumer 9 million kids with asthma in the USA alone 80% of children with asthma take Albuterol Pricing $10/month (based on comps) Market size $720M in USA alone MedHerance – Confidential and Proprietary

Opportunity: Providers and Payers 1.8 million ED visits annually 15-54% of hospitalizations for asthma are preventable Avg cost of ED visit for asthma ~$2100 Preventable costs ~$500million MedHerance – Confidential and Proprietary

Competitive Analysis GeckoCap – Smart Cap for inhaler – $60 upfront + $10/month Propeller Health – Smart Cap for inhaler (FDA approved) – $14.5M Series B MedHerance advantage – Monitor physiological response – Use pre-existing hardware (no upfront purchases) MedHerance – Confidential and Proprietary

Proof of Concept (MVP) MedHerance – Confidential and Proprietary

Next Step: Further Validation Create app for Samsung Gear Fit wearable – Collect data from Asthma patients – Analyze data to develop analytics algorithms MedHerance – Confidential and Proprietary

Other Use Cases Arrhythmia (heart rate) Beta-blocker adherence (heart rate) Diabetes (glucometry) Smoking Cessation (heart rate & pulse oximetry) MedHerance – Confidential and Proprietary

Team Tara Mac Aulay, Pharm D– Pharmacist Asim Qadir, MBA – Healthcare Mobile Development Frank Wang, PhD – Stanford Biodesign Fellow Amit Agarwal – Marketing Victor Chen, PhD – Engineer Saumya Garg – Biomedical and CS MedHerance – Confidential and Proprietary

We Notify Sam’s Parents and PCP Analytics Identify: Abnormal events Notify: Real time/ Weekly reports MedHerance – Confidential and Proprietary