Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR ‐ bound and RBR ‐ free complexes by Zoltán Magyar, Beatrix Horváth, Safina.

Slides:



Advertisements
Similar presentations
NgBR is essential for endothelial cell glycosylation and vascular development by Eon Joo Park, Kariona A Grabińska, Ziqiang Guan, and William C Sessa EMBO.
Advertisements

Induction of cyclin E–cdk2 kinase activity, E2F ‐ dependent transcription and cell growth by Myc are genetically separable events by Rudolf Beier, Andrea.
The anti ‐ hypertensive drug prazosin inhibits glioblastoma growth via the PKCδ ‐ dependent inhibition of the AKT pathway by Suzana Assad Kahn, Silvia.
Structure of the SSB–DNA polymerase III interface and its role in DNA replication by Aimee H Marceau, Soon Bahng, Shawn C Massoni, Nicholas P George, Steven.
Transcriptional targets shared by estrogen receptor ‐ related receptors (ERRs) and estrogen receptor (ER) α, but not by ERβ by Jean ‐ Marc Vanacker, Katarina.
RNA polymerase II kinetics in polo polyadenylation signal selection by Pedro A B Pinto, Telmo Henriques, Marta O Freitas, Torcato Martins, Rita G Domingues,
Ca 2+ ‐ independent insulin exocytosis induced by α ‐ latrotoxin requires latrophilin, a G protein ‐ coupled receptor by Jochen Lang, Yuri Ushkaryov, Alfonso.
Mutations in RNAs of both ribosomal subunits cause defects in translation termination by Alexey L. Arkov, David V. Freistroffer, Måns Ehrenberg, and Emanuel.
Two RING finger proteins mediate cooperation between ubiquitin ‐ conjugating enzymes in DNA repair by Helle D. Ulrich, and Stefan Jentsch EMBO J. Volume.
Formation of a nucleoprotein complex containing Tn7 and its target DNA regulates transposition initiation by Zachary Skelding, Robert Sarnovsky, and Nancy.
Molecular aging and rejuvenation of human muscle stem cells by Morgan E. Carlson, Charlotte Suetta, Michael J. Conboy, Per Aagaard, Abigail Mackey, Michael.
Neuropeptide Y regulates the hematopoietic stem cell microenvironment and prevents nerve injury in the bone marrow by Min Hee Park, Hee Kyung Jin, Woo.
TGFβ signaling directs serrated adenomas to the mesenchymal colorectal cancer subtype by Evelyn Fessler, Jarno Drost, Sander R van Hooff, Janneke F Linnekamp,
Transgenic tobacco expressing a foreign calmodulin gene shows an enhanced production of active oxygen species by Scott A. Harding, Suk ‐ Heung Oh, and.
MiRNA ‐ dependent gene silencing involving Ago2 ‐ mediated cleavage of a circular antisense RNA by Thomas B Hansen, Erik D Wiklund, Jesper B Bramsen, Sune.
Modulation of NF ‐ κB ‐ dependent transcription and cell survival by the SIRT1 deacetylase by Fan Yeung, Jamie E Hoberg, Catherine S Ramsey, Michael D.
Disruption of the trypanothione reductase gene of Leishmania decreases its ability to survive oxidative stress in macrophages by Carole Dumas, Marc Ouellette,
SIP, a novel ankyrin repeat containing protein, sequesters steroid receptor coactivators in the cytoplasm by Ying Zhang, Hua Zhang, Jing Liang, Wenhua.
A viral protein inhibits the long range signaling activity of the gene silencing signal by Hui Shan Guo, and Shou Wei Ding EMBO J. Volume 21(3):
OPA1 ‐ dependent cristae modulation is essential for cellular adaptation to metabolic demand by David A Patten, Jacob Wong, Mireille Khacho, Vincent Soubannier,
Activation of HER4 by heparin ‐ binding EGF ‐ like growth factor stimulates chemotaxis but not proliferation by Klaus Elenius, Subroto Paul, Genève Allison,
AID ‐ expressing epithelium is protected from oncogenic transformation by an NKG2D surveillance pathway by Arantxa Pérez ‐ García, Pablo Pérez ‐ Durán,
Dim ‐ 2 encodes a DNA methyltransferase responsible for all known cytosine methylation in Neurospora by Elena Kouzminova, and Eric U. Selker EMBO J. Volume.
Flexibility in crosstalk between H2B ubiquitination and H3 methylation in vivo by Hanneke Vlaming, Tibor van Welsem, Erik L de Graaf, David Ontoso, AF.
The interaction between uPAR and vitronectin triggers ligand ‐ independent adhesion signalling by integrins by Gian Maria Sarra Ferraris, Carsten Schulte,
A novel site for ubiquitination: the N ‐ terminal residue, and not internal lysines of MyoD, is essential for conjugation and degradation of the protein.
Bringing next ‐ generation diagnostics to the clinic through synthetic biology by Alexis Courbet, Eric Renard, and Franck Molina EMBO Mol Med. Volume ():e
Mutations in XPB and XPD helicases found in xeroderma pigmentosum patients impair the transcription function of TFIIH by Frédéric Coin, Etienne Bergmann,
Visualization of RNA–protein interactions in living cells: FMRP and IMP1 interact on mRNAs by Oliver Rackham, and Chris M Brown EMBO J. Volume 23(16):
Quantification of intracellular fuzzy staining (A) and of spherical bodies (B) in root cells upon an NaCl treatment. Quantification of intracellular fuzzy.
Import of NH‐Idp3p‐, PTS‐1 (3HAD)‐ and PTS2 (3‐ketoacyl‐CoA thiolase)‐containing proteins in wild‐type, Δpex5 and Δpex7 cells. Import of NH‐Idp3p‐, PTS‐1.
AO domain of LSD1 is responsible for its interaction with Snail1.
Role of C-terminal phosphorylation in the subcellular localization of AtPIP2;1.A, the figure shows typical laser-scanning confocal micrographs of the fluorescence.
Electrostatic Fasteners Hold the T Cell Receptor-CD3 Complex Together
Functional properties of pRb.
Control of IL‐6 synthesis by ζPKC and RelA Ser311 phosphorylation.
p53 and Apoptosis: It's Not Just in the Nucleus Anymore
Pericycle Current Biology
Mutations affecting HOIP–UBA and HOIL‐1L–UBL interaction that compromise NF‐κB activation. Mutations affecting HOIP–UBA and HOIL‐1L–UBL interaction that.
Plant meristems: A ménage à trois to end it all
Laura Lancaster, Harry F. Noller  Molecular Cell 
Regulating Sister Chromatid Separation by Separase Phosphorylation
The MSP domain of MOSPD2 is sufficient to interact with STARD3 and STARD3NL The MSP domain of MOSPD2 is sufficient to interact with STARD3 and STARD3NL.
Karin Johanna Ferrari, Elisa Lavarone, Diego Pasini  Molecular Cell 
Volume 6, Issue 7, Pages (July 1996)
Eukaryotic Transcription Activation: Right on Target
Percentage of proteins identified in envelope membrane extracts according to the purification method and the number of transmembrane domains. Percentage.
Hypersensitive cell death response after genotoxic stress only partially depends on SOG1 upon RBR silencing Hypersensitive cell death response after genotoxic.
Model of the involvement of phosphorylation in the regulation of motility in S. acidocaldarius. Model of the involvement of phosphorylation in the regulation.
The evolutionary conservation of the phosphoproteomes.a, E. coli. b, B. subtilis. The evolutionary conservation of the phosphoproteomes.a, E. coli. b,
BIRC6 is expressed in the tumorigenic Aldefluorhigh fraction of colonosphere cells. BIRC6 is expressed in the tumorigenic Aldefluorhigh fraction of colonosphere.
Colonopshere-enriched proteins display functional interactions.
New Insights into Genome Structure: Genes of a Feather Stick Together
Nuclear Decay Factors Crack Up mRNA
Molecular mechanism of STING-mediated inhibition of the mTORC1 pathway
Pericycle Current Biology
Model depicting the sorting of endolysosomal proteins in the Golgi complex. Model depicting the sorting of endolysosomal proteins in the Golgi complex.
Brandon J. Thomas, Stephen T. Smale  Immunity 
Stem Cells: A Plant Biology Perspective
The Cell Biology of Genomes: Bringing the Double Helix to Life
Eight serum analytes with greatest differences in levels between clinically infected and non-infected neonates. Eight serum analytes with greatest differences.
TC-1 silencing sensitized A549 and SPC-A-1 cells to radiation therapy
Hypothetical model of HvAP2 control of stem elongation.
Jefri Heyman, Lieven De Veylder  Molecular Plant 
PRC1 Marks the Difference in Plant PcG Repression
Volume 25, Issue 2, Pages (January 2007)
Γ-Tubulin Is Essential for Acentrosomal Microtubule Nucleation and Coordination of Late Mitotic Events in Arabidopsis by Pavla Binarová, Vera Cenklová,
Volume 15, Issue 6, Pages (March 2005)
Figure 5-1 Molecular Biology of the Cell (© Garland Science 2008)
Model of the change in receptor structure on engagement of the ligand IFN-γ. Model of the change in receptor structure on engagement of the ligand IFN-γ.
Presentation transcript:

Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR ‐ bound and RBR ‐ free complexes by Zoltán Magyar, Beatrix Horváth, Safina Khan, Binish Mohammed, Rossana Henriques, Lieven De Veylder, László Bakó, Ben Scheres, and László Bögre EMBO J. Volume 31(6): March 21, 2012 ©2012 by European Molecular Biology Organization

Both RBR1 and E2FA are present in proliferating cells in Arabidopsis roots and leaves. Zoltán Magyar et al. EMBO J. 2012;31: ©2012 by European Molecular Biology Organization

E2FA silencing leads to compromised cell proliferation and endocycle. Zoltán Magyar et al. EMBO J. 2012;31: ©2012 by European Molecular Biology Organization

RBR1 makes complex with E2FA in proliferating cells while it associates with E2FB in cells leaving cell proliferation. Zoltán Magyar et al. EMBO J. 2012;31: ©2012 by European Molecular Biology Organization

The pE2FA::gE2FA–GFP lines have increased expression of E2FA within its own expression domain that leads to more proliferation and endocycle compared with WT. (A) Two independent pE2FA::gE2FA–GFP lines (line 2/10 and line 81/11) were tested for the expressi... Zoltán Magyar et al. EMBO J. 2012;31: ©2012 by European Molecular Biology Organization

E2FA interaction with RBR1 is required for the repression of premature cell elongation and endocycle. Zoltán Magyar et al. EMBO J. 2012;31: ©2012 by European Molecular Biology Organization

Model explaining the functions of E2FA and E2FB in proliferating and in endocycling cells. Zoltán Magyar et al. EMBO J. 2012;31: ©2012 by European Molecular Biology Organization