Sonic hedgehog mediates a novel pathway of PDGF-BB– dependent vessel maturation by Qinyu Yao, Marie-Ange Renault, Candice Chapouly, Soizic Vandierdonck,

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Presentation transcript:

Sonic hedgehog mediates a novel pathway of PDGF-BB– dependent vessel maturation by Qinyu Yao, Marie-Ange Renault, Candice Chapouly, Soizic Vandierdonck, Isabelle Belloc, Béatrice Jaspard-Vinassa, Jean-Marie Daniel-Lamazière, Muriel Laffargue, Aksam Merched, Claude Desgranges, and Alain-Pierre Gadeau Blood Volume 123(15): April 10, 2014 ©2014 by American Society of Hematology

Shh mediates PDGF-BB chemotactic effect on SMCs. (A) PDGF-BB–stimulated (10 ng/mL) and nonstimulated (Ctrl) SMC migration was assessed in the presence of the Smo inhibitor cyclopamine (Cyclop; 1 µmol/L), the Hh blocking antibody 5E1 (1.5 µg/mL), an siRNA di... Qinyu Yao et al. Blood 2014;123: ©2014 by American Society of Hematology

PDGF-BB stimulates Shh expression in SMCs. (A) SMCs were treated with 10 ng/mL PDGF-BB for 6 hours. Qinyu Yao et al. Blood 2014;123: ©2014 by American Society of Hematology

PDGF-BB–induced SMC migration implicates Shh-mediated PI3Kγ activation. Qinyu Yao et al. Blood 2014;123: ©2014 by American Society of Hematology

Shh is required to sustain ERK1/2 phosphorylation induced by PDGF-BB. Qinyu Yao et al. Blood 2014;123: ©2014 by American Society of Hematology

PDGF-BB–dependent Shh expression in VEGF-mediated corneal angiogenesis model. Qinyu Yao et al. Blood 2014;123: ©2014 by American Society of Hematology

Inhibition of Hh signaling pathway stimulates neovessel maturation and stability. Qinyu Yao et al. Blood 2014;123: ©2014 by American Society of Hematology

Role of autocrine Shh signaling in the potentiation of PDGF-BB–induced SMC migration and recruitment. Qinyu Yao et al. Blood 2014;123: ©2014 by American Society of Hematology