Preserving Prostaglandin E2 Level Prevents Rejection of Implanted Allogeneic Mesenchymal Stem Cells and Restores Postinfarction Ventricular Function by.

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Presentation transcript:

Preserving Prostaglandin E2 Level Prevents Rejection of Implanted Allogeneic Mesenchymal Stem Cells and Restores Postinfarction Ventricular Function by Sanjiv Dhingra, Peng Li, Xi-Ping Huang, Jian Guo, Jun Wu, Anton Mihic, Shu- Hong Li, Wang-Fu Zang, Daniel Shen, Richard D. Weisel, Pawan K. Singal, and Ren-Ke Li Circulation Volume 128(11 suppl 1):S69-S78 September 10, 2013 Copyright © American Heart Association, Inc. All rights reserved.

Differentiation of mesenchymal stem cells (MSCs) decreased prostaglandin E2 (PGE2), cyclooxygenase 2 (COX2), and prostaglandin E synthase-1 (PTGES1) levels. Sanjiv Dhingra et al. Circulation. 2013;128:S69-S78 Copyright © American Heart Association, Inc. All rights reserved.

Prostaglandin E2 (PGE2) decrease in differentiated mesenchymal stem cells (D-MSCs) was associated with the loss of immunoprivilege. Sanjiv Dhingra et al. Circulation. 2013;128:S69-S78 Copyright © American Heart Association, Inc. All rights reserved.

Prostaglandin E2 (PGE2) decrease in differentiated mesenchymal stem cells (D-MSCs) was associated with loss of T regulatory (Treg) cell induction. Sanjiv Dhingra et al. Circulation. 2013;128:S69-S78 Copyright © American Heart Association, Inc. All rights reserved.

Prostaglandin E2 (PGE2) maintained mesenchymal stem cell (MSC) chemotactic ability. Sanjiv Dhingra et al. Circulation. 2013;128:S69-S78 Copyright © American Heart Association, Inc. All rights reserved.

Chemokines maintained mesenchymal stem cell (MSC) immunoprivilege. Sanjiv Dhingra et al. Circulation. 2013;128:S69-S78 Copyright © American Heart Association, Inc. All rights reserved.

Prostaglandin E2 (PGE2) increased survival of transplanted mesenchymal stem cells (MSCs) in the heart and alleviated the host immune response. Sanjiv Dhingra et al. Circulation. 2013;128:S69-S78 Copyright © American Heart Association, Inc. All rights reserved.

In vivo differentiation of transplanted mesenchymal stem cells (MSCs). Sanjiv Dhingra et al. Circulation. 2013;128:S69-S78 Copyright © American Heart Association, Inc. All rights reserved.

Maintaining prostaglandin E2 (PGE2) levels in transplanted mesenchymal stem cells (MSCs) preserved heart function. Sanjiv Dhingra et al. Circulation. 2013;128:S69-S78 Copyright © American Heart Association, Inc. All rights reserved.