The E3 ligase synoviolin controls body weight and mitochondrial biogenesis through negative regulation of PGC ‐ 1β by Hidetoshi Fujita, Naoko Yagishita,

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The E3 ligase synoviolin controls body weight and mitochondrial biogenesis through negative regulation of PGC ‐ 1β by Hidetoshi Fujita, Naoko Yagishita, Satoko Aratani, Tomoko Saito ‐ Fujita, Saori Morota, Yoshihisa Yamano, Magnus J Hansson, Masato Inazu, Hiroko Kokuba, Katsuko Sudo, Eiichi Sato, Ko ‐ ichi Kawahara, Fukami Nakajima, Daisuke Hasegawa, Itsuro Higuchi, Tomoo Sato, Natsumi Araya, Chie Usui, Kenya Nishioka, Yu Nakatani, Ikuro Maruyama, Masahiko Usui, Naomi Hara, Hiroyuki Uchino, Eskil Elmer, Kusuki Nishioka, and Toshihiro Nakajima EMBO J. Volume 34(8): April 15, 2015 ©2015 by European Molecular Biology Organization

Body weight and WAT in post ‐ neonatal Syvn1 mutant mice Hidetoshi Fujita et al. EMBO J. 2015;34: ©2015 by European Molecular Biology Organization

Changes in body weight and WAT in post ‐ neonatal Syvn1 knockout (KO) and genetically obese (ob/ob and db/db) mice Hidetoshi Fujita et al. EMBO J. 2015;34: ©2015 by European Molecular Biology Organization

Effect of adipose tissue ‐ specific Syvn1 deletion on body weight and fat mass Hidetoshi Fujita et al. EMBO J. 2015;34: ©2015 by European Molecular Biology Organization

PGC ‐ 1β is a substrate of SYVN1 Hidetoshi Fujita et al. EMBO J. 2015;34: ©2015 by European Molecular Biology Organization

Regulation of PGC ‐ 1β function by SYVN1 Hidetoshi Fujita et al. EMBO J. 2015;34: ©2015 by European Molecular Biology Organization

Effect of SYVN1 inhibition on diet ‐ induced weight gain or genetic obesity Hidetoshi Fujita et al. EMBO J. 2015;34: ©2015 by European Molecular Biology Organization