Percutaneous Nerve Evaluation Test Versus Staged Test Trials for Sacral Neuromodulation: Sensitivity, Specificity, and Predictive Values of Each Technique.

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Percutaneous Nerve Evaluation Test Versus Staged Test Trials for Sacral Neuromodulation: Sensitivity, Specificity, and Predictive Values of Each Technique Mai Banakhar 1, Magdy Hassouna 2 1 King Abdulaziz University, Faculty of Medicine, Jeddah, Saudi Arabia 2 University of Toronto, University Health Network, Toronto Western Hospital, Toronto, Canada This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Interna tional Neurourology Journal 2016;20:

INTRODUCTION InterStim device is an U.S. Food and Drug Administration approved minimal invasive therapy for sacral neuromodulation for lower urinary tract dysfunction.\ Before InterStim implantation, a trial with the appropriate screening tests is required to determine patient therapy eligibility. There are two different techniques for patient screening: percutaneous nerve evaluation (PNE) test and staged test. However, test sensitivity and predictive values of either test have not been studied. The aim of our study was to determine the sensitivity and specificity of each test and to establish a decision algorithm for the most appropriate testing method to be used as a screening test. Interna tional Neurourology Journal 2016;20:

MATERIALS AND METHODS This cross-sectional study was conducted from August 2009 to February 2012 and included patients with lower urinary tract dysfunction who participated in the stimulation test trial. Patients underwent PNE as the first stimulation test, while those who encountered technical difficulty during PNE or electrode migration underwent staged testing. Interna tional Neurourology Journal 2016;20:

A total of 213 patients, including 172 female and 41 male subjects, underwent PNE. The patients’ diagnoses included refractory overactive bladder (47.9%), nonobstructive urinary retention (29.6%), and frequency urgency syndrome (22.1%). A total of 202 patients were screened with PNE and 10 patients with staged testing. Overall sensitivity of PNE was 87.3%, and it was 90% for staged test. PNE specificity was 98.5% as compared to 92.9% for staged test. Positive and negative predictive values for PNE were 99% and 82.1% and for staged test were 90% and 92.9%, respectively. RESULTS CONCLUSIONS PNE test has high specificity and positive predictive value. We recommend PNE, a simple office-based, less expensive procedure as the first option for screening. Interna tional Neurourology Journal 2016;20:

Table 1. Patients demographic Interna tional Neurourology Journal 2016;20:

Table 2. Primary analysis of sensitivity and specificity for PNE test versus staged test trial

Interna tional Neurourology Journal 2016;20: Table 3. Pearson correlation between primary analysis result and patient’s age, sex, and diagnosis

Interna tional Neurourology Journal 2016;20: Table 4. Sensitivity, specificity for PNE test versus staged test trial in refractory overactive bladder

Interna tional Neurourology Journal 2016;20: Table 5. Sensitivity, specificity for PNE test versus staged test trial in chronic retention

Interna tional Neurourology Journal 2016;20: Table 6. Sensitivity, specificity for PNE test versus staged test trial in frequency- urgency syndrome, pelvic pain

Interna tional Neurourology Journal 2016;20:

Fig. 1. Decision algorithm for selection of test trial. PNE, percutaneous nerve evaluation. InterStim (Medtronic Inc., Minneapolis, MN, USA).