[1] Ophir, Jonathan, et al. "Elastography: a quantitative method for imaging the elasticity of biological tissues." Ultrasonic imaging (1991) [2] Muthupillai,

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Presentation transcript:

[1] Ophir, Jonathan, et al. "Elastography: a quantitative method for imaging the elasticity of biological tissues." Ultrasonic imaging (1991) [2] Muthupillai, R., et al. "Magnetic resonance elastography by direct visualization of propagating acoustic strain waves." Science (1995)

Air-pulse OCE ( cornea ) [3] mm-OCE (Rat liver and chicken muscle) [6] Mechanical actuator for tissue phantom [4] [3] Wang, Shang, and Kirill V. Larin. "Shear wave imaging optical coherence tomography (SWI-OCT) for ocular tissue biomechanics." Optics letters (2014) [4] Nguyen, Thu-Mai, et al. "Shear wave pulse compression for dynamic elastogrcoherence tomography." Journal of biomedical optics (2014) [5] Song, Shaozhen, et al. "Quantitative shear-wave optical coherence elastography with a programmable phased array ultrasound as the wave source." Optics letters (2015) [6] Ahmad, Adeel, et al. "Magnetomotive optical coherence elastography using magnetic particles to induce mechanical waphy using phase-sensitive optical aves." Biomedical optics express (2014) Ultrasound as wave source (porcine retina) [5]

Megahertz Optical Coherence Elastography  ~1.5 MHz A-scan rate  New scanning mechanism compared to conventional OCE

Sample Air-pulse Excitation OCT Scan Path [3] Wang, Shang, and Kirill V. Larin. "Shear wave imaging optical coherence tomography (SWI-OCT) for ocular tissue biomechanics." Optics letters (2014)

Sample Air-pulse Excitation OCT Scan Path

 Megahertz OCE system ~1.5 MHz A-scan rate 4X Buffered FDML OptoRes Gmbh 1316 nm central wavelength 100 nm bandwidth 16 µm axial resolution Up to 160 mW of power 7.3 kHz resonant scanner  Lorentz force excitation system Waveform generator Power amplifier Two magnets Probe

Future work  Improve the SNR of displacement signal; Electrical current Magnetic field Tissue conductivity  Analyze tissue viscoelasticity by elastic wave dispersion  Frequency analysis